Nitric oxide signaling pathways involved in the inhibition of spontaneous activity in the guinea pig prostate

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Purpose: We investigated nitric oxide mediated inhibition of spontaneous activity recorded in young and aging guinea pig prostates. Materials and Methods: Conventional intracellular microelectrode and tension recording techniques were used. Results: The nitric oxide donor sodium nitroprusside (10 ?M) abolished spontaneous contractions and slow wave activity in 5 young and 5 aging prostates. Upon adding the nitric oxide synthase inhibitor L-NAME (10 ?M) the frequency of spontaneous contractile and electrical activity was significantly increased in each age group. This increase was significantly larger in 4 to 8 preparations of younger vs aging prostates (about 40 to 50 vs about 10 to 20 , 2-way ANOVA p
Original languageEnglish
Pages (from-to)2254 - 2260
Number of pages7
JournalJournal of Urology
Issue number6
Publication statusPublished - 2012

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