Abstract
Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system. Specifically, the N-3-aminopyridinyl myristylamine (NAPyM) + phytantriol mixture formed a lamellar phase in excess aqueous environment. The NAPyM + phytantriol LLC responded to the nitric oxide gas as a chemical stimulus which triggers a phase transition from lamellar phase to inverse cubic and hexagonal phase. The nitric oxide-triggered phase transition of the LLC accelerated the release of encapsulated model drug from the LLC bulk phase, resulting in a 15-fold increase in the diffusion coefficient compared to the starting lamellar structure. The nitric oxide-sensing LLC system has potential application in the development of smart medicines to treat nitric oxide implicated diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 517-524 |
| Number of pages | 8 |
| Journal | Journal of Colloid and Interface Science |
| Volume | 508 |
| DOIs | |
| Publication status | Published - 15 Dec 2017 |
Keywords
- Cubic phase
- Drug release
- Liquid crystal
- Nitric oxide
- Stimuli responsive
Cite this
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Nitric oxide-sensing actuators for modulating structure in lipid-based liquid crystalline drug delivery systems. / Liu, Qingtao; Hu, Jinming; Whittaker, Michael R.; Davis, Thomas P.; Boyd, Ben J.
In: Journal of Colloid and Interface Science, Vol. 508, 15.12.2017, p. 517-524.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Nitric oxide-sensing actuators for modulating structure in lipid-based liquid crystalline drug delivery systems
AU - Liu, Qingtao
AU - Hu, Jinming
AU - Whittaker, Michael R.
AU - Davis, Thomas P.
AU - Boyd, Ben J.
PY - 2017/12/15
Y1 - 2017/12/15
N2 - Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system. Specifically, the N-3-aminopyridinyl myristylamine (NAPyM) + phytantriol mixture formed a lamellar phase in excess aqueous environment. The NAPyM + phytantriol LLC responded to the nitric oxide gas as a chemical stimulus which triggers a phase transition from lamellar phase to inverse cubic and hexagonal phase. The nitric oxide-triggered phase transition of the LLC accelerated the release of encapsulated model drug from the LLC bulk phase, resulting in a 15-fold increase in the diffusion coefficient compared to the starting lamellar structure. The nitric oxide-sensing LLC system has potential application in the development of smart medicines to treat nitric oxide implicated diseases.
AB - Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system. Specifically, the N-3-aminopyridinyl myristylamine (NAPyM) + phytantriol mixture formed a lamellar phase in excess aqueous environment. The NAPyM + phytantriol LLC responded to the nitric oxide gas as a chemical stimulus which triggers a phase transition from lamellar phase to inverse cubic and hexagonal phase. The nitric oxide-triggered phase transition of the LLC accelerated the release of encapsulated model drug from the LLC bulk phase, resulting in a 15-fold increase in the diffusion coefficient compared to the starting lamellar structure. The nitric oxide-sensing LLC system has potential application in the development of smart medicines to treat nitric oxide implicated diseases.
KW - Cubic phase
KW - Drug release
KW - Liquid crystal
KW - Nitric oxide
KW - Stimuli responsive
UR - http://www.scopus.com/inward/record.url?scp=85028721934&partnerID=8YFLogxK
U2 - 10.1016/j.jcis.2017.08.079
DO - 10.1016/j.jcis.2017.08.079
M3 - Article
VL - 508
SP - 517
EP - 524
JO - Journal of Colloid and Interface Science
JF - Journal of Colloid and Interface Science
SN - 0021-9797
ER -