Nitric oxide-sensing actuators for modulating structure in lipid-based liquid crystalline drug delivery systems

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system. Specifically, the N-3-aminopyridinyl myristylamine (NAPyM) + phytantriol mixture formed a lamellar phase in excess aqueous environment. The NAPyM + phytantriol LLC responded to the nitric oxide gas as a chemical stimulus which triggers a phase transition from lamellar phase to inverse cubic and hexagonal phase. The nitric oxide-triggered phase transition of the LLC accelerated the release of encapsulated model drug from the LLC bulk phase, resulting in a 15-fold increase in the diffusion coefficient compared to the starting lamellar structure. The nitric oxide-sensing LLC system has potential application in the development of smart medicines to treat nitric oxide implicated diseases.

Original languageEnglish
Pages (from-to)517-524
Number of pages8
JournalJournal of Colloid and Interface Science
Volume508
DOIs
Publication statusPublished - 15 Dec 2017

Keywords

  • Cubic phase
  • Drug release
  • Liquid crystal
  • Nitric oxide
  • Stimuli responsive

Cite this

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title = "Nitric oxide-sensing actuators for modulating structure in lipid-based liquid crystalline drug delivery systems",
abstract = "Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system. Specifically, the N-3-aminopyridinyl myristylamine (NAPyM) + phytantriol mixture formed a lamellar phase in excess aqueous environment. The NAPyM + phytantriol LLC responded to the nitric oxide gas as a chemical stimulus which triggers a phase transition from lamellar phase to inverse cubic and hexagonal phase. The nitric oxide-triggered phase transition of the LLC accelerated the release of encapsulated model drug from the LLC bulk phase, resulting in a 15-fold increase in the diffusion coefficient compared to the starting lamellar structure. The nitric oxide-sensing LLC system has potential application in the development of smart medicines to treat nitric oxide implicated diseases.",
keywords = "Cubic phase, Drug release, Liquid crystal, Nitric oxide, Stimuli responsive",
author = "Qingtao Liu and Jinming Hu and Whittaker, {Michael R.} and Davis, {Thomas P.} and Boyd, {Ben J.}",
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language = "English",
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journal = "Journal of Colloid and Interface Science",
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publisher = "Elsevier",

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Nitric oxide-sensing actuators for modulating structure in lipid-based liquid crystalline drug delivery systems. / Liu, Qingtao; Hu, Jinming; Whittaker, Michael R.; Davis, Thomas P.; Boyd, Ben J.

In: Journal of Colloid and Interface Science, Vol. 508, 15.12.2017, p. 517-524.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Hu, Jinming

AU - Whittaker, Michael R.

AU - Davis, Thomas P.

AU - Boyd, Ben J.

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AB - Herein we report on the development of a nitric oxide-sensing lipid-based liquid crystalline (LLC) system specifically designed to release encapsulated drugs on exposure to NO through a stimulated phase change. A series of nitric oxide (NO)-sensing lipids compatible with phytantriol and GMO cubic phases were designed and synthesized, and utilized in enabling nitric oxide-sensing LLC systems. The nitric oxide (NO)-sensing lipids react with nitric oxide, resulting in hydrolysis of these lipids and phase transition of the LLC system. Specifically, the N-3-aminopyridinyl myristylamine (NAPyM) + phytantriol mixture formed a lamellar phase in excess aqueous environment. The NAPyM + phytantriol LLC responded to the nitric oxide gas as a chemical stimulus which triggers a phase transition from lamellar phase to inverse cubic and hexagonal phase. The nitric oxide-triggered phase transition of the LLC accelerated the release of encapsulated model drug from the LLC bulk phase, resulting in a 15-fold increase in the diffusion coefficient compared to the starting lamellar structure. The nitric oxide-sensing LLC system has potential application in the development of smart medicines to treat nitric oxide implicated diseases.

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