Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages

Benjamin J. Marsland, Michael Kurrer, Regina Reissmann, Nicola L. Harris, Manfred Kopf

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Chronic obstructive pulmonary disease (COPD) is the 5th most prevalent disease worldwide leading to severe morbidity and mortality in developed countries. The disease is strongly associated with smoking, and can be characterized by progressive and irreversible deterioration in lung function and destruction of the lung parenchyma. We show here that infection with the hookworm Nippostrongylus brasiliensis results in deterioration in lung function, destruction of alveoli and long-term airways hyperresponsiveness, consistent with COPD and emphysema. N. brasiliensis infection leads to chronic low level hemorrhaging in the lung and the presence of hemosiderinladen macrophages in the absence of an overt inflammatory infiltrate. Microarray analysis of gene expression in diseased lungs and quantitative RT-PCR analysis of purified macrophages revealed a state of prolonged tissue injury and the presence of alternatively activated macrophages producing MMP-12. Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema.

Original languageEnglish
Pages (from-to)479-488
Number of pages10
JournalEuropean Journal of Immunology
Volume38
Issue number2
DOIs
Publication statusPublished - 1 Feb 2008
Externally publishedYes

Keywords

  • Chronic
  • Emphysema
  • Lung
  • Parasite
  • Th2

Cite this

@article{60597d06587d4ebcb7a14c996aad928c,
title = "Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages",
abstract = "Chronic obstructive pulmonary disease (COPD) is the 5th most prevalent disease worldwide leading to severe morbidity and mortality in developed countries. The disease is strongly associated with smoking, and can be characterized by progressive and irreversible deterioration in lung function and destruction of the lung parenchyma. We show here that infection with the hookworm Nippostrongylus brasiliensis results in deterioration in lung function, destruction of alveoli and long-term airways hyperresponsiveness, consistent with COPD and emphysema. N. brasiliensis infection leads to chronic low level hemorrhaging in the lung and the presence of hemosiderinladen macrophages in the absence of an overt inflammatory infiltrate. Microarray analysis of gene expression in diseased lungs and quantitative RT-PCR analysis of purified macrophages revealed a state of prolonged tissue injury and the presence of alternatively activated macrophages producing MMP-12. Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema.",
keywords = "Chronic, Emphysema, Lung, Parasite, Th2",
author = "Marsland, {Benjamin J.} and Michael Kurrer and Regina Reissmann and Harris, {Nicola L.} and Manfred Kopf",
year = "2008",
month = "2",
day = "1",
doi = "10.1002/eji.200737827",
language = "English",
volume = "38",
pages = "479--488",
journal = "European Journal of Immunology",
issn = "0014-2980",
publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",
number = "2",

}

Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages. / Marsland, Benjamin J.; Kurrer, Michael; Reissmann, Regina; Harris, Nicola L.; Kopf, Manfred.

In: European Journal of Immunology, Vol. 38, No. 2, 01.02.2008, p. 479-488.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Nippostrongylus brasiliensis infection leads to the development of emphysema associated with the induction of alternatively activated macrophages

AU - Marsland, Benjamin J.

AU - Kurrer, Michael

AU - Reissmann, Regina

AU - Harris, Nicola L.

AU - Kopf, Manfred

PY - 2008/2/1

Y1 - 2008/2/1

N2 - Chronic obstructive pulmonary disease (COPD) is the 5th most prevalent disease worldwide leading to severe morbidity and mortality in developed countries. The disease is strongly associated with smoking, and can be characterized by progressive and irreversible deterioration in lung function and destruction of the lung parenchyma. We show here that infection with the hookworm Nippostrongylus brasiliensis results in deterioration in lung function, destruction of alveoli and long-term airways hyperresponsiveness, consistent with COPD and emphysema. N. brasiliensis infection leads to chronic low level hemorrhaging in the lung and the presence of hemosiderinladen macrophages in the absence of an overt inflammatory infiltrate. Microarray analysis of gene expression in diseased lungs and quantitative RT-PCR analysis of purified macrophages revealed a state of prolonged tissue injury and the presence of alternatively activated macrophages producing MMP-12. Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema.

AB - Chronic obstructive pulmonary disease (COPD) is the 5th most prevalent disease worldwide leading to severe morbidity and mortality in developed countries. The disease is strongly associated with smoking, and can be characterized by progressive and irreversible deterioration in lung function and destruction of the lung parenchyma. We show here that infection with the hookworm Nippostrongylus brasiliensis results in deterioration in lung function, destruction of alveoli and long-term airways hyperresponsiveness, consistent with COPD and emphysema. N. brasiliensis infection leads to chronic low level hemorrhaging in the lung and the presence of hemosiderinladen macrophages in the absence of an overt inflammatory infiltrate. Microarray analysis of gene expression in diseased lungs and quantitative RT-PCR analysis of purified macrophages revealed a state of prolonged tissue injury and the presence of alternatively activated macrophages producing MMP-12. Taken together, these data show that lung tissue damage caused by hookworm infection can result in the development of COPD and emphysema.

KW - Chronic

KW - Emphysema

KW - Lung

KW - Parasite

KW - Th2

UR - http://www.scopus.com/inward/record.url?scp=42249093361&partnerID=8YFLogxK

U2 - 10.1002/eji.200737827

DO - 10.1002/eji.200737827

M3 - Article

VL - 38

SP - 479

EP - 488

JO - European Journal of Immunology

JF - European Journal of Immunology

SN - 0014-2980

IS - 2

ER -