The Suspicion Index (SI) screening tool was developed to identify patients suspected of having Niemann-Pick disease type C (NP-C). The SI provides a risk prediction score (RPS) based on NP-C manifestations within and across domains (visceral, neurological and psychiatric). The aim of these subanalyses was to further examine the discriminatory power of the SI by age and manifestation-associations by NP-C suspicion-level and leading manifestations.
Wraith, J. E., Sedel, F., Pineda, M., Wijburg, F., Hendriksz, C., Fahey, M. C.
, ... Kolb, S. (2014). Niemann-Pick type C Suspicion Index tool: analyses by age and association of manifestations
. Journal of Inherited Metabolic Disease
(1), 93 - 101. https://doi.org/10.1007/s10545-013-9626-y