NF-k(kappa)B subunit specificity in hemopoiesis.

Steven Demetrious Gerondakis, Ashish Banerjee, George Grigoriadis, Ajithkumar Vasanthakumar, Raffi Gugasyan, Tom Sidwell, Raelene Joy Grumont

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38 Citations (Scopus)

Abstract

Although the diverse functions served by the nuclear factor-I?B (NF-I?B) pathway in virtually all cell types are typically employed to deal with stress responses, NF-I?B transcription factors also play key roles in the development of hemopoietic cells. This review focuses on how NF-I?B transcription factors control various aspects of thymic T-cell and myeloid cell differentiation that include its roles in hemopoietic precursors, conventional I?I? T cells, CD4 + regulatory T cells, natural killer T cells, I?I T cells, macrophages, and dendritic cells. A? 2012 John Wiley Sons A/S.
Original languageEnglish
Pages (from-to)272 - 285
Number of pages14
JournalImmunological Reviews
Volume246
Issue number1
DOIs
Publication statusPublished - 2012

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