TY - JOUR
T1 - NF-k(kappa)B subunit specificity in hemopoiesis.
AU - Gerondakis, Steven Demetrious
AU - Banerjee, Ashish
AU - Grigoriadis, George
AU - Vasanthakumar, Ajithkumar
AU - Gugasyan, Raffi
AU - Sidwell, Tom
AU - Grumont, Raelene Joy
PY - 2012
Y1 - 2012
N2 - Although the diverse functions served by the nuclear factor-I?B (NF-I?B) pathway in virtually all cell types are typically employed to deal with stress responses, NF-I?B transcription factors also play key roles in the development of hemopoietic cells. This review focuses on how NF-I?B transcription factors control various aspects of thymic T-cell and myeloid cell differentiation that include its roles in hemopoietic precursors, conventional I?I? T cells, CD4 + regulatory T cells, natural killer T cells, I?I T cells, macrophages, and dendritic cells. A? 2012 John Wiley Sons A/S.
AB - Although the diverse functions served by the nuclear factor-I?B (NF-I?B) pathway in virtually all cell types are typically employed to deal with stress responses, NF-I?B transcription factors also play key roles in the development of hemopoietic cells. This review focuses on how NF-I?B transcription factors control various aspects of thymic T-cell and myeloid cell differentiation that include its roles in hemopoietic precursors, conventional I?I? T cells, CD4 + regulatory T cells, natural killer T cells, I?I T cells, macrophages, and dendritic cells. A? 2012 John Wiley Sons A/S.
UR - http://onlinelibrary.wiley.com/doi/10.1111/j.1600-065X.2011.01090.x/pdf
U2 - 10.1111/j.1600-065X.2011.01090.x
DO - 10.1111/j.1600-065X.2011.01090.x
M3 - Article
SN - 0105-2896
VL - 246
SP - 272
EP - 285
JO - Immunological Reviews
JF - Immunological Reviews
IS - 1
ER -