NF-kappaB signaling in skeletal muscle: prospects for intervention in muscle diseases

Foteini Mourkioti, Nadia Alicia Rosenthal

Research output: Contribution to journalArticleResearchpeer-review

85 Citations (Scopus)

Abstract

Muscle remodeling is an important physiological process that promotes adaptive changes in cytoarchitecture and protein composition after exercise, aging, or disease conditions. Numerous transcription factors have been reported to regulate skeletal muscle homeostasis. NF-kappaB is a major pleiotropic transcription factor modulating immune, inflammatory, cell survival, and proliferating responses; however, its role in muscle development, physiology, and disease has just started to be elucidated. The current review article aims to summarize the literature on the role of NF-kappaB signaling in skeletal muscle pathophysiology, investigated over the last years using in vitro and more recently in vivo systems. Understanding the exact role of NF-kappaB in muscle cells will allow better therapeutic manipulations in the setting of human muscle diseases.
Original languageEnglish
Pages (from-to)747 - 759
Number of pages13
JournalJournal of Molecular Medicine
Volume86
Issue number7
Publication statusPublished - 2008
Externally publishedYes

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