NF-{kappa}B control of T cell development

Steven Demetrious Gerondakis, Thomas Fulford, Nicole L Messina, Raelene Joy Grumont

Research output: Contribution to journalArticleResearchpeer-review

129 Citations (Scopus)

Abstract

The NF- kappa B signal transduction pathway is best known as a major regulator of innate and adaptive immune responses, yet there is a growing appreciation of its importance in immune cell development, particularly of T lineage cells. In this Review, we discuss how the temporal regulation of NF-?B controls the stepwise differentiation and antigen-dependent selection of conventional and specialized subsets of T cells in response to T cell receptor and costimulatory, cytokine and growth factor signals.
Original languageEnglish
Pages (from-to)15 - 25
Number of pages11
JournalNature Immunology
Volume15
Issue number1
DOIs
Publication statusPublished - 2014

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