Abstract
NF-κB (nuclear factor of κB site binding) proteins are an evolutionarily conserved family of inducible transcription factors that control the expression of a large number of genes with important developmental and effector functions in a variety of immune cells. Mice with genetic knockouts of individual genes encoding NF-κB proteins have distinct immune cell defects. Moreover, impaired regulation of NF-κB is found in many human immune diseases. For example, NF-κB is constitutively active in many chronic inflammatory diseases and leukemias/lymphomas, while depressed NF-κB activity is seen in some human immunodeficiencies. Thus, NF-κB is viewed as a therapeutic target for many immune cell diseases.
Original language | English |
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Title of host publication | Encyclopedia of Cell Biology |
Editors | Ralph A. Bradshaw, Philip D. Stahl |
Publisher | Academic Press |
Pages | 580-587 |
Number of pages | 8 |
Volume | 3 |
ISBN (Electronic) | 9780123944474 |
ISBN (Print) | 9780123947963 |
DOIs | |
Publication status | Published - 1 Jan 2015 |
Keywords
- Acquired immunity
- B cells
- Development
- Immune response
- Innate immunity
- Lymphoma
- NF-kappaB
- Rel
- Signal transduction
- T cells
- Transcription factor