NF-kappaB and the Immune System

Thomas D Gilmore, T.W. Siggers, S Gerondakis

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)

Abstract

NF-κB (nuclear factor of κB site binding) proteins are an evolutionarily conserved family of inducible transcription factors that control the expression of a large number of genes with important developmental and effector functions in a variety of immune cells. Mice with genetic knockouts of individual genes encoding NF-κB proteins have distinct immune cell defects. Moreover, impaired regulation of NF-κB is found in many human immune diseases. For example, NF-κB is constitutively active in many chronic inflammatory diseases and leukemias/lymphomas, while depressed NF-κB activity is seen in some human immunodeficiencies. Thus, NF-κB is viewed as a therapeutic target for many immune cell diseases.

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
EditorsRalph A. Bradshaw, Philip D. Stahl
PublisherAcademic Press
Pages580-587
Number of pages8
Volume3
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
DOIs
Publication statusPublished - 1 Jan 2015

Keywords

  • Acquired immunity
  • B cells
  • Development
  • Immune response
  • Innate immunity
  • Lymphoma
  • NF-kappaB
  • Rel
  • Signal transduction
  • T cells
  • Transcription factor

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