NF-kappaB and the Immune System

Thomas D Gilmore, T.W. Siggers, S Gerondakis

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

2 Citations (Scopus)


NF-κB (nuclear factor of κB site binding) proteins are an evolutionarily conserved family of inducible transcription factors that control the expression of a large number of genes with important developmental and effector functions in a variety of immune cells. Mice with genetic knockouts of individual genes encoding NF-κB proteins have distinct immune cell defects. Moreover, impaired regulation of NF-κB is found in many human immune diseases. For example, NF-κB is constitutively active in many chronic inflammatory diseases and leukemias/lymphomas, while depressed NF-κB activity is seen in some human immunodeficiencies. Thus, NF-κB is viewed as a therapeutic target for many immune cell diseases.

Original languageEnglish
Title of host publicationEncyclopedia of Cell Biology
EditorsRalph A. Bradshaw, Philip D. Stahl
PublisherAcademic Press
Number of pages8
ISBN (Electronic)9780123944474
ISBN (Print)9780123947963
Publication statusPublished - 1 Jan 2015


  • Acquired immunity
  • B cells
  • Development
  • Immune response
  • Innate immunity
  • Lymphoma
  • NF-kappaB
  • Rel
  • Signal transduction
  • T cells
  • Transcription factor

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