NF-κB1 can inhibit v-Abl-induced lymphoid transformation by functioning as a negative regulator of cyclin D1 expression

Yukio Nakamura, Raelene J. Grumont, Steve Gerondakis

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Mounting evidence implicates deregulated Rel/NF-κB signaling as a common feature of lymphoid malignancies. Despite the fact that they promote the survival and proliferation of normal lymphocytes, the underlying mechanisms by which various Rel/NF-κB proteins with different transcriptional regulatory capacities might facilitate transformation remain to be established. Here we show that the proliferation and tumorigenicity of Abelson murine leukemia virus (A-MuLV)-transformed pre-B cells are enhanced in the absence of NF-κB1 and that this coincides with elevated levels of cyclin D1. Support for a link between cyclin D1 expression and v-Abl transformation came from the finding that proliferation of transformed pre-B cells was reduced in the absence of cyclin D1, while enforced cyclin D1 expression increased the proliferation and tumorigenicity of wild-type transformants. A reduction in endogenous cyclin D1 levels that coincided with NF-κB1 transgene reversal of enhanced nfkbl-/- pre-B-cell transformation, coupled with NF-κB1 inhibition of v-Abl-induced κB-dependent murine cyclin D1 transcription, lends support to a model in which v-Abl-induced cyclin D1 transcription in transformed pre-B cells is controlled by Rel/NF-κB dimers with different activities.

Original languageEnglish
Pages (from-to)5563-5574
Number of pages12
JournalMolecular and Cellular Biology
Issue number15
Publication statusPublished - 22 Jul 2002
Externally publishedYes

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