New synthetic approaches towards analogues of bedaquiline

Daniel L. Priebbenow, Lisa Barbaro, Jonathan B. Baell

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control the worldwide spread of tuberculosis (TB). Bedaquiline has recently emerged as a new drug developed to specifically treat MDR-TB. Despite being highly effective as a result of its unique mode of action, bedaquiline has been associated with significant toxicities and as such, safety concerns are limiting its clinical use. In order to access pharmaceutical agents that exhibit an improved safety profile for the treatment of MDR-TB, new synthetic pathways to facilitate the preparation of bedaquiline and analogues thereof have been discovered.

Original languageEnglish
Pages (from-to)9622-9628
Number of pages7
JournalOrganic and Biomolecular Chemistry
Volume14
Issue number40
DOIs
Publication statusPublished - 28 Oct 2016

Cite this

Priebbenow, Daniel L. ; Barbaro, Lisa ; Baell, Jonathan B. / New synthetic approaches towards analogues of bedaquiline. In: Organic and Biomolecular Chemistry. 2016 ; Vol. 14, No. 40. pp. 9622-9628.
@article{678e679213444b688e0a771669169e96,
title = "New synthetic approaches towards analogues of bedaquiline",
abstract = "Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control the worldwide spread of tuberculosis (TB). Bedaquiline has recently emerged as a new drug developed to specifically treat MDR-TB. Despite being highly effective as a result of its unique mode of action, bedaquiline has been associated with significant toxicities and as such, safety concerns are limiting its clinical use. In order to access pharmaceutical agents that exhibit an improved safety profile for the treatment of MDR-TB, new synthetic pathways to facilitate the preparation of bedaquiline and analogues thereof have been discovered.",
author = "Priebbenow, {Daniel L.} and Lisa Barbaro and Baell, {Jonathan B.}",
year = "2016",
month = "10",
day = "28",
doi = "10.1039/c6ob01893a",
language = "English",
volume = "14",
pages = "9622--9628",
journal = "Organic and Biomolecular Chemistry",
issn = "1477-0520",
publisher = "The Royal Society of Chemistry",
number = "40",

}

New synthetic approaches towards analogues of bedaquiline. / Priebbenow, Daniel L.; Barbaro, Lisa; Baell, Jonathan B.

In: Organic and Biomolecular Chemistry, Vol. 14, No. 40, 28.10.2016, p. 9622-9628.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - New synthetic approaches towards analogues of bedaquiline

AU - Priebbenow, Daniel L.

AU - Barbaro, Lisa

AU - Baell, Jonathan B.

PY - 2016/10/28

Y1 - 2016/10/28

N2 - Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control the worldwide spread of tuberculosis (TB). Bedaquiline has recently emerged as a new drug developed to specifically treat MDR-TB. Despite being highly effective as a result of its unique mode of action, bedaquiline has been associated with significant toxicities and as such, safety concerns are limiting its clinical use. In order to access pharmaceutical agents that exhibit an improved safety profile for the treatment of MDR-TB, new synthetic pathways to facilitate the preparation of bedaquiline and analogues thereof have been discovered.

AB - Multi-drug resistant tuberculosis (MDR-TB) is of growing global concern and threatens to undermine increasing efforts to control the worldwide spread of tuberculosis (TB). Bedaquiline has recently emerged as a new drug developed to specifically treat MDR-TB. Despite being highly effective as a result of its unique mode of action, bedaquiline has been associated with significant toxicities and as such, safety concerns are limiting its clinical use. In order to access pharmaceutical agents that exhibit an improved safety profile for the treatment of MDR-TB, new synthetic pathways to facilitate the preparation of bedaquiline and analogues thereof have been discovered.

UR - http://www.scopus.com/inward/record.url?scp=84991698450&partnerID=8YFLogxK

U2 - 10.1039/c6ob01893a

DO - 10.1039/c6ob01893a

M3 - Article

VL - 14

SP - 9622

EP - 9628

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

SN - 1477-0520

IS - 40

ER -