New rearranged limonoids from Walsura cochinchinensis

Mei Ling Han, Yu Shen, Ying Leng, Hua Zhang, Jian Min Yue

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Sixteen new limonoids, walsucochinoids C-R (1-16) incorporating a rearranged carbon skeleton, were isolated from the twigs and leaves of Walsura cochinchinensis. Their structures were established by detailed interpretation of spectroscopic data with those of 1 and 10 being secured by single-crystal X-ray diffraction experiments. Bioassays revealed that walsucochinoids D (2) and E (3) were mild mouse and human 11β-HSD1 inhibitors with IC50 values of 13.4 ± 1.7 and 8.25 ± 0.69 μM, respectively.

Original languageEnglish
Pages (from-to)19150-19158
Number of pages9
JournalRSC Advances
Volume4
Issue number37
DOIs
Publication statusPublished - 2014
Externally publishedYes

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