TY - JOUR
T1 - New possibilities in hepatocellular carcinoma treatment
AU - Rasool, Mahmood
AU - Rashid, Sana
AU - Arooj, Mahwish
AU - Ansari, Shakeel Ahmed
AU - Khan, Khalid Mahmud
AU - Malik, Arif
AU - Naseer, Muhammad Imran
AU - Zahid, Sara
AU - Manan, Abdul
AU - Asif, Muhammad
AU - Razzaq, Zarish
AU - Ashraf, Sadia
AU - Qazi, Mahmood Husain
AU - Iqbal, Zafar
AU - Gan, Siew Hua
AU - Kamal, Mohammad Amjad
AU - Sheikh, Ishfaq Ahmed
PY - 2014/4/1
Y1 - 2014/4/1
N2 - Hepatocellular carcinoma diagnosis and treatment has witnessed many major changes and challenges in the past two decades. Increasing incidence of HCC has introduced new monitoring systems and increased the efficacy of screening tests, as well as prognosis of the disease, including the staging system, serological testing and diagnostic imaging. Moreover, surgical resection, liver transplantation and herbal therapy have improved treatment. The most encouraging specific serological marker for HCC is alpha fetoprotein (AFP), which, along with ultrasonography, has improved earlier detection of HCC. Most recently, circulating tumor cell measurement has emerged as a promising tool for the prognosis of HCC. Herbal drugs and herbal composite formula drugs are promising towards the prevention of invasion and proliferation of tumor cells. Chemotherapeutic agents, such as sorafenib, bevacizumab and erlotinib, which target growth factor receptors in signaling pathways, are also used as HCC treatments. Furthermore, radiotherapy is employed in the treatment of unresectable tumors. The present report provides an analysis of the above parameters in the management of HCC.
AB - Hepatocellular carcinoma diagnosis and treatment has witnessed many major changes and challenges in the past two decades. Increasing incidence of HCC has introduced new monitoring systems and increased the efficacy of screening tests, as well as prognosis of the disease, including the staging system, serological testing and diagnostic imaging. Moreover, surgical resection, liver transplantation and herbal therapy have improved treatment. The most encouraging specific serological marker for HCC is alpha fetoprotein (AFP), which, along with ultrasonography, has improved earlier detection of HCC. Most recently, circulating tumor cell measurement has emerged as a promising tool for the prognosis of HCC. Herbal drugs and herbal composite formula drugs are promising towards the prevention of invasion and proliferation of tumor cells. Chemotherapeutic agents, such as sorafenib, bevacizumab and erlotinib, which target growth factor receptors in signaling pathways, are also used as HCC treatments. Furthermore, radiotherapy is employed in the treatment of unresectable tumors. The present report provides an analysis of the above parameters in the management of HCC.
KW - Alpha fetoprotein
KW - Chemo and radiotherapy for HCC
KW - Hepatocellular carcinoma
KW - Herbal drugs
KW - Review.
KW - Surgical resection
UR - http://www.scopus.com/inward/record.url?scp=84902299593&partnerID=8YFLogxK
M3 - Article
C2 - 24692683
AN - SCOPUS:84902299593
SN - 0250-7005
VL - 34
SP - 1563
EP - 1572
JO - Anticancer Research
JF - Anticancer Research
IS - 4
ER -