Projects per year
Abstract
A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.
Original language | English |
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Pages (from-to) | 1496-1501 |
Number of pages | 6 |
Journal | Nucleic Acids Research |
Volume | 44 |
Issue number | 4 |
DOIs | |
Publication status | Published - 14 Jan 2016 |
Keywords
- genome
- heterochromatin
- histones
- molecular chaperones
- alpha-thalassemia
- mental retardation syndrome
- nondeletion type
- x-linked
Projects
- 1 Finished
-
Epigenetic regulation of centromere and telomere chromatin
Australian Research Council (ARC), Monash University
1/01/15 → 31/12/18
Project: Research