New players in heterochromatin silencing: Histone variant H3.3 and the ATRX/DAXX chaperone

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Abstract

A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.
Original languageEnglish
Pages (from-to)1496-1501
Number of pages6
JournalNucleic Acids Research
Volume44
Issue number4
DOIs
Publication statusPublished - 14 Jan 2016

Keywords

  • genome
  • heterochromatin
  • histones
  • molecular chaperones
  • alpha-thalassemia
  • mental retardation syndrome
  • nondeletion type
  • x-linked

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