New players in heterochromatin silencing: Histone variant H3.3 and the ATRX/DAXX chaperone

Hsiao P.J. Voon; Lee H. Wong

doi:10.1093/nar/gkw012

New players in heterochromatin silencing: Histone variant H3.3 and the ATRX/DAXX chaperone

Hsiao P.J. Voon, Lee H. Wong

Research output: Contribution to journal › Short Survey › Other › peer-review

50 Citations (Scopus)

Abstract

A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.

Original language	English
Pages (from-to)	1496-1501
Number of pages	6
Journal	Nucleic Acids Research
Volume	44
Issue number	4
DOIs	https://doi.org/10.1093/nar/gkw012
Publication status	Published - 14 Jan 2016

Keywords

genome
heterochromatin
histones
molecular chaperones
alpha-thalassemia
mental retardation syndrome
nondeletion type
x-linked

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10.1093/nar/gkw012

3594231-oaFinal published version, 348 KB

RM sElocation

1 Finished

Epigenetic regulation of centromere and telomere chromatin
Wong, L.
Australian Research Council (ARC), Monash University
1/01/15 → 31/12/18
Project: Research

Cite this

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abstract = "A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.",

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T2 - Histone variant H3.3 and the ATRX/DAXX chaperone

AU - Voon, Hsiao P.J.

AU - Wong, Lee H.

PY - 2016/1/14

Y1 - 2016/1/14

N2 - A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.

AB - A number of studies have demonstrated that various components of the ATRX/DAXX/Histone H3.3 complex are important for heterochromatin silencing at multiple genomic regions. We provide an overview of the individual components (ATRX, DAXX and/or H3.3) tested in each study and propose a model where the ATRX/DAXX chaperone complex deposits H3.3 to maintain the H3K9me3 modification at heterochromatin throughout the genome.

KW - genome

KW - heterochromatin

KW - histones

KW - molecular chaperones

KW - alpha-thalassemia

KW - mental retardation syndrome

KW - nondeletion type

KW - x-linked

UR - http://www.ncbi.nlm.nih.gov/pubmed/26773061

U2 - 10.1093/nar/gkw012

DO - 10.1093/nar/gkw012

M3 - Short Survey

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EP - 1501

JO - Nucleic Acids Research

JF - Nucleic Acids Research

SN - 0305-1048

IS - 4

ER -

New players in heterochromatin silencing: Histone variant H3.3 and the ATRX/DAXX chaperone

Abstract

Keywords

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Projects

Epigenetic regulation of centromere and telomere chromatin

Cite this