New insights into the structure and function of the plasminogen/plasmin system

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Plasminogen is the zymogen form of plasmin, an enzyme that plays a fundamental role in the dissolution of fibrin clots, the extracellular matrix and other key proteins involved in immunity and tissue repair. Comprising seven distinct domains (an N-terminal Pan-apple domain (PAp), 5 kringle domains (KR) and the serine protease domain (SP)), plasminogen undergoes a complex, incompletely understood conformational change that is key to its activation. Here, we review our current understanding of the structural basis for plasminogen activation with regard to new insights derived from crystallographic and biochemical studies.
Original languageEnglish
Pages (from-to)836 - 841
Number of pages6
JournalCurrent Opinion in Structural Biology
Issue number6
Publication statusPublished - 2013

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