New insights into the roles of ReL/NF-κB transcription factors in immune function, hemopoiesis and human disease

Mathis Grossmann, Yukio Nakamura, Raelene Grumont, Steve Gerondakis

Research output: Contribution to journalReview ArticleResearchpeer-review

66 Citations (Scopus)

Abstract

In mammals, Rel/NF-κB proteins are a small family of transcription factors which serve as pivotal regulators of immune, inflammatory and acute phase responses. Pathways leading to the activation of Rel/NF-κB have recently been dissected in some detail and shown to converge on a unique high molecular weight cytoplasmic complex that includes several kinases and regulatory molecules. Moreover, gene targeting experiments have identified novel roles for Rel/NF-κB proteins in the development and maturation of hemopoietic precursors as well as in the function of mature cells in the immune system. These include regulating the cell cycle, controlling cell survival and providing a link between the innate and adaptive immune systems. Since the dysregulation of Rel/NF-κB function is associated with various pathologies including inflammatory and neoplastic disease, new insights into the role of Rel/NF-κB in human disease may provide a basis for therapeutic strategies in the treatment of chronic inflammatory diseases and certain malignancies. Copyright (C) 1999 Elsevier Science Ltd.

Original languageEnglish
Pages (from-to)1209-1219
Number of pages11
JournalInternational Journal of Biochemistry & Cell Biology
Volume31
Issue number10
DOIs
Publication statusPublished - 1 Oct 1999

Keywords

  • Hemopoiesis
  • Immune function
  • NF-κB
  • Rel
  • Transcription

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