TY - JOUR
T1 - New insights into the effects of primary hyperparathyroidism on the cortical and trabecular compartments of bone
AU - Vu, Thuy D.T.
AU - Wang, Xiao Fang
AU - Wang, Qingju
AU - Cusano, Natalie E.
AU - Irani, Dinaz
AU - Silva, Barbara C.
AU - Ghasem-Zadeh, Ali
AU - Udesky, Julia
AU - Romano, Megan E.
AU - Zebaze, Roger
AU - Jerums, George
AU - Boutroy, Stephanie
AU - Bilezikian, John P.
AU - Seeman, Ego
PY - 2013/7/1
Y1 - 2013/7/1
N2 - In primary hyperparathyroidism (PHPT), protracted elevation of serum parathyroid hormone (PTH) is held to be associated with cortical, but not trabecular, bone loss. However, an alternative explanation for the apparent preservation of trabecular bone is fragmentation of the cortex by intracortical remodeling. The cortical fragments resemble trabeculae and so may be erroneously included in the quantification of 'trabecular' bone density.To test this hypothesis, we compared bone microarchitecture in 43 patients with untreated PHPT (mean 62.9. years, range 31-84) with 47 healthy age-matched controls and 25 patients with surgically treated PHPT (63.6. years, 30-82). Images of the distal radius and tibia were acquired using high-resolution peripheral quantitative CT and analysed using StrAx1.0, a new software program that quantifies bone morphology in-vivo. Results were expressed as the mean number of standardized deviations (SD) from the age-specific mean (Z scores, mean ± SEM).In subjects with PHPT, total tibial cortical area was reduced - 0.26 ± 0.08 SD; p = 0.002). Cortical volumetric bone mineral density (vBMD) was reduced (- 0.29 ± 0.06 SD; p < 0.001) due to higher cortical porosity (0.32 ± 0.06 SD; p < 0.001) and lower tissue mineralization density (- 0.21 ± 0.06 SD; p = 0.002). Medullary area was increased (0.26 ± 0.08 SD; p = 0.002) and trabecular vBMD was reduced (- 0.14 ± 0.04 SD; p < 0.001).In subjects who underwent successful parathyroidectomy, cortical area (- 0.18 ± 0.10 SD; NS) and medullary area (0.18 ± 0.10 SD; NS) did not differ from controls. Cortical vBMD was reduced (- 0.15 ± 0.05 SD; p = 0.003) due to high porosity (0.15 ± 0.05 SD; p = 0.006), values numerically lower than in untreated PHPT. Tissue mineralization density (- 0.26 ± 0.04 SD; p < 0.001) and trabecular vBMD were reduced (- 0.16 ± 0.04 SD, p < 0.001). The results were similar in the distal radius.In PHPT, chronically elevated endogenous PTH does not spare trabecular bone; it causes bone loss and microarchitectural deterioration in both cortical and trabecular compartments of bone.
AB - In primary hyperparathyroidism (PHPT), protracted elevation of serum parathyroid hormone (PTH) is held to be associated with cortical, but not trabecular, bone loss. However, an alternative explanation for the apparent preservation of trabecular bone is fragmentation of the cortex by intracortical remodeling. The cortical fragments resemble trabeculae and so may be erroneously included in the quantification of 'trabecular' bone density.To test this hypothesis, we compared bone microarchitecture in 43 patients with untreated PHPT (mean 62.9. years, range 31-84) with 47 healthy age-matched controls and 25 patients with surgically treated PHPT (63.6. years, 30-82). Images of the distal radius and tibia were acquired using high-resolution peripheral quantitative CT and analysed using StrAx1.0, a new software program that quantifies bone morphology in-vivo. Results were expressed as the mean number of standardized deviations (SD) from the age-specific mean (Z scores, mean ± SEM).In subjects with PHPT, total tibial cortical area was reduced - 0.26 ± 0.08 SD; p = 0.002). Cortical volumetric bone mineral density (vBMD) was reduced (- 0.29 ± 0.06 SD; p < 0.001) due to higher cortical porosity (0.32 ± 0.06 SD; p < 0.001) and lower tissue mineralization density (- 0.21 ± 0.06 SD; p = 0.002). Medullary area was increased (0.26 ± 0.08 SD; p = 0.002) and trabecular vBMD was reduced (- 0.14 ± 0.04 SD; p < 0.001).In subjects who underwent successful parathyroidectomy, cortical area (- 0.18 ± 0.10 SD; NS) and medullary area (0.18 ± 0.10 SD; NS) did not differ from controls. Cortical vBMD was reduced (- 0.15 ± 0.05 SD; p = 0.003) due to high porosity (0.15 ± 0.05 SD; p = 0.006), values numerically lower than in untreated PHPT. Tissue mineralization density (- 0.26 ± 0.04 SD; p < 0.001) and trabecular vBMD were reduced (- 0.16 ± 0.04 SD, p < 0.001). The results were similar in the distal radius.In PHPT, chronically elevated endogenous PTH does not spare trabecular bone; it causes bone loss and microarchitectural deterioration in both cortical and trabecular compartments of bone.
KW - Bone microarchitecture
KW - Cortical porosity
KW - High-resolution peripheral quantitative computed tomography
KW - Parathyroid hormone excess
KW - Tissue mineralization density
UR - http://www.scopus.com/inward/record.url?scp=84877026021&partnerID=8YFLogxK
U2 - 10.1016/j.bone.2013.03.009
DO - 10.1016/j.bone.2013.03.009
M3 - Article
C2 - 23541782
AN - SCOPUS:84877026021
SN - 8756-3282
VL - 55
SP - 57
EP - 63
JO - Bone
JF - Bone
IS - 1
ER -
