TY - JOUR
T1 - New insights into signalling networks regulating breast cancer stem cells
AU - Swarbrick, Alexander
AU - Daly, Roger John
PY - 2012
Y1 - 2012
N2 - ABSTRACT: In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target.
AB - ABSTRACT: In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22999218
U2 - 10.1186/bcr3209
DO - 10.1186/bcr3209
M3 - Article
SN - 1465-5411
VL - 14
SP - 1
EP - 10
JO - Breast Cancer Research
JF - Breast Cancer Research
IS - 5
ER -
