New insights into signalling networks regulating breast cancer stem cells

Alexander Swarbrick, Roger John Daly

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)


ABSTRACT: In a recent paper, Aceto and colleagues report that Src homology 2 domain-containing protein tyrosine phosphatase 2 (Shp2) plays a critical role in maintenance of breast tumour-initiating cells, and they define novel effectors downstream of Shp2 that regulate cellular invasion and self-renewal, including the transcription factors c-Myc and zinc finger E-box binding homeobox 1 and the suppressor of miRNA biogenesis lin-28 homolog B. These findings provide important mechanistic insights into breast tumourigenesis and highlight Shp2 as a potential therapeutic target.
Original languageEnglish
Pages (from-to)1 - 10
Number of pages10
JournalBreast Cancer Research
Issue number5
Publication statusPublished - 2012
Externally publishedYes

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