Research output per year
Research output per year
Sarah E. Hetrick, Nicholas Meader, Alan P. Bailey, Paul B. Badcock, Carl I. Moller, Georgina R. Cox, Sally N. Merry, Joanne E. McKenzie
Research output: Contribution to journal › Article › Research › peer-review
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To investigate, via network meta-analyses (NMA), the comparative effectiveness and safety of different newer generation antidepressants in children and adolescents with a diagnosed major depressive disorder (MDD). Specific objectives, in order of priority, are to:. estimate the relative effects of newer generation antidepressants compared with placebo and with each other on depression, functioning, suicide-related outcomes and other adverse outcomes; estimate the relative ranking of the included newer generation antidepressants for the outcomes of depression, functioning, suicide-related outcomes and other adverse outcomes; and, examine whether the relative effects on clinician-rated depression symptoms and suicide-related outcomes estimated in objectives 1 and 2 are modified by age, treatment duration, baseline severity and pharmaceutical industry funding of the antidepressant under evaluation.
Original language | English |
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Article number | CD013674 |
Number of pages | 22 |
Journal | Cochrane Database of Systematic Reviews |
Volume | 2020 |
Issue number | 7 |
DOIs | |
Publication status | Published - 9 Jul 2020 |
Research output: Contribution to journal › Review Article › Research › peer-review