TY - JOUR
T1 - New evidence, supporting an association between attention deficit hyperactivity disorder and the DRD5 locus in the IRISH population
AU - Lowe, N. T.
AU - Hawi, Z.
AU - Kirley, A.
AU - Mullins, C.
AU - Fitzgerald, M.
AU - Gill, M.
PY - 2001/10/8
Y1 - 2001/10/8
N2 - Abnormalities in the dopaminergic system have been proposed as contributory factors in the development of Attention Deficit Hyperactivity Disorder (ADHD). Recently, we reported preferential transmission of a 148 bp allele of a highly polymorphic microsatellite marker located 18.5 kb from the 5′ end of the DRD5 dopamine receptor on chromosome 4 (Daly et al., 1999). We have now examined this (CA)n repeat with a new study sample consisting of 56 trios (mother, father and affected child) and 2 duos (either parent and affected child), diagnosed according to the DSM - IV criteria. As in our previous sample the microsatellite marker was found to have twelve alleles with the 148 bp allele being the most frequent at 45.7%. HHRR (Haplotype Based Haplotype Relative Risk) showed significant preferential transmission of the 148 bp allele (Chisquare = 4.11, P <0.05). These findings are supported by Tahir et al., (2000), and Barr et al., (2000). Thus, we have replicated our previous findings in a new sample derived from the same population and conclude that DNA variants at or near DRD5 confer risk for the development of ADHD.
AB - Abnormalities in the dopaminergic system have been proposed as contributory factors in the development of Attention Deficit Hyperactivity Disorder (ADHD). Recently, we reported preferential transmission of a 148 bp allele of a highly polymorphic microsatellite marker located 18.5 kb from the 5′ end of the DRD5 dopamine receptor on chromosome 4 (Daly et al., 1999). We have now examined this (CA)n repeat with a new study sample consisting of 56 trios (mother, father and affected child) and 2 duos (either parent and affected child), diagnosed according to the DSM - IV criteria. As in our previous sample the microsatellite marker was found to have twelve alleles with the 148 bp allele being the most frequent at 45.7%. HHRR (Haplotype Based Haplotype Relative Risk) showed significant preferential transmission of the 148 bp allele (Chisquare = 4.11, P <0.05). These findings are supported by Tahir et al., (2000), and Barr et al., (2000). Thus, we have replicated our previous findings in a new sample derived from the same population and conclude that DNA variants at or near DRD5 confer risk for the development of ADHD.
UR - http://www.scopus.com/inward/record.url?scp=33749088041&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:33749088041
VL - 105
SP - 635
JO - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
JF - American Journal of Medical Genetics Part B: Neuropsychiatric Genetics
SN - 1552-4841
IS - 7
ER -