TY - JOUR
T1 - New developments in dry powder pulmonary vaccine delivery
AU - Sou, Tomas
AU - Meeusen, Elza
AU - de Veer, Michael John
AU - Morton, David
AU - Kaminskas, Lisa
AU - McIntosh, Michelle Paula
PY - 2011
Y1 - 2011
N2 - Pulmonary immunization has gained increased recognition
as a means of triggering both a mucosal and systemic
immune response without the use of needles. The
appropriate formulation of antigens in a dry, solid state
can result in improved stability, thereby removing coldchain
storage complications associated with conventional
liquid-based vaccines. The particulate nature of
dry powder vaccines could also induce a better immune
response. This review describes our current understanding
of pulmonary immunization, including possible barriers
facing the development of pulmonary vaccines, and
discusses recent advances in spray-drying technologies
applicable to the production of dry powder formulations
for pulmonary vaccine delivery.
AB - Pulmonary immunization has gained increased recognition
as a means of triggering both a mucosal and systemic
immune response without the use of needles. The
appropriate formulation of antigens in a dry, solid state
can result in improved stability, thereby removing coldchain
storage complications associated with conventional
liquid-based vaccines. The particulate nature of
dry powder vaccines could also induce a better immune
response. This review describes our current understanding
of pulmonary immunization, including possible barriers
facing the development of pulmonary vaccines, and
discusses recent advances in spray-drying technologies
applicable to the production of dry powder formulations
for pulmonary vaccine delivery.
U2 - 10.1016/j.tibtech.2010.12.009
DO - 10.1016/j.tibtech.2010.12.009
M3 - Article
SN - 0167-7799
VL - 29
SP - 191
EP - 198
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 4
ER -
