New developments in dry powder pulmonary vaccine delivery

Tomas Sou, Elza Meeusen, Michael John de Veer, David Morton, Lisa Kaminskas, Michelle Paula McIntosh

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101 Citations (Scopus)


Pulmonary immunization has gained increased recognition as a means of triggering both a mucosal and systemic immune response without the use of needles. The appropriate formulation of antigens in a dry, solid state can result in improved stability, thereby removing coldchain storage complications associated with conventional liquid-based vaccines. The particulate nature of dry powder vaccines could also induce a better immune response. This review describes our current understanding of pulmonary immunization, including possible barriers facing the development of pulmonary vaccines, and discusses recent advances in spray-drying technologies applicable to the production of dry powder formulations for pulmonary vaccine delivery.
Original languageEnglish
Pages (from-to)191 - 198
Number of pages8
JournalTrends in Biotechnology
Issue number4
Publication statusPublished - 2011

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