New concepts on the etiology of endometriosis

Fiona L. Cousins, Brett D. McKinnon, Sally Mortlock, Harriet C. Fitzgerald, Chenyu Zhang, Grant W. Montgomery, Caroline E. Gargett

Research output: Contribution to journalArticleOtherpeer-review

11 Citations (Scopus)

Abstract

Endometriosis is a serious, chronic disorder where endometrial tissue grows outside the uterus, causing severe pelvic pain and infertility. It affects 11% of women. Endometriosis is a multifactorial disorder of unclear etiology, although retrograde menstruation plays a major role. It has a genetic component with over 40 genetic risk factors mapped, although their mechanism of action is still emerging. New evidence suggests a role for retrograde menstruation of endometrial stem/progenitor cells, now that identifying markers of these cells are available. Recent lineage tracing and tissue clearing microscopy and 3D reconstruction has provided new understanding of endometrial glandular structure, particularly the horizontal orientation and interconnection of basalis glands. New sequencing technologies, particularly whole genome DNA sequencing are revealing somatic mutations, including in cancer driver genes, in normal and eutopic endometrium of patients with endometriosis, as well as ectopic endometriotic lesions. Methylome sequencing is offering insight into the regulation of genes and the role of the environmental factors. Single cell RNA sequencing reveals the transcriptome of individual endometrial cells, shedding new light on the diversity and range of cellular subpopulations of the major cell types present in the endometrium and in endometriotic lesions. New endometrial epithelial organoid cultures replicating glandular epithelium are providing tractable models for studying endometriosis. Organoids derived from menstrual fluid offer a non-invasive source of endometrial tissue and a new avenue for testing drugs and developing personalized medicine for treating endometriosis. These new approaches are rapidly advancing our understanding of endometriosis etiology.

Original languageEnglish
Pages (from-to)1090-1105
Number of pages16
JournalThe Journal of Obstetrics and Gynaecology Research
Volume49
Issue number4
DOIs
Publication statusPublished - Apr 2023

Keywords

  • endometrial stem/progenitor cells
  • endometriosis
  • genetic variants
  • retrograde menstruation
  • somatic mutations

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