New cholinesterase inhibitors from Garcinia atroviridis

Wen Nee Tan, Melati Khairuddean, Keng Chong Wong, Kooi Yeong Khaw, Murugaiyah Vikneswaran

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


A triflavanone, Garcineflavanone A (1) and a biflavonol, Garcineflavonol A (2) have been isolated from the stem bark of Garcinia atroviridis (Clusiaceae), collected in Peninsular Malaysia. Their structures were established using one and two-dimensional NMR, UV, IR and mass spectrometry and evaluated in vitro for their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes inhibitory activity. Molecular docking studies of the isolated compounds were performed using docking procedure of AutoDock to disclose the binding interaction and orientation of these molecules into the active site gorge.

Original languageEnglish
Pages (from-to)261-267
Number of pages7
Publication statusPublished - Sep 2014
Externally publishedYes


  • Cholinesterase enzymes inhibitory activity
  • Clusiaceae
  • Garcinia atroviridis
  • Stem bark

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