New Approaches to Investigate Drug-Induced Hypersensitivity

Monday O. Ogese; Shaheda Ahmed; Ana Alferivic; Catherine J. Betts; Anne Dickinson; Lee Faulkner; Neil French; Andrew Gibson; Gideon M. Hirschfield; Michael Kammüller; Xiaoli Meng; Stefan F. Martin; Philippe Musette; Alan Norris; Munir Pirmohamed; B. Kevin Park; Anthony W. Purcell; Colin F. Spraggs; Jessica Whritenour; Dean J. Naisbitt

doi:10.1021/acs.chemrestox.6b00333

New Approaches to Investigate Drug-Induced Hypersensitivity

Monday O. Ogese, Shaheda Ahmed, Ana Alferivic, Catherine J. Betts, Anne Dickinson, Lee Faulkner, Neil French, Andrew Gibson, Gideon M. Hirschfield, Michael Kammüller, Xiaoli Meng, Stefan F. Martin, Philippe Musette, Alan Norris, Munir Pirmohamed, B. Kevin Park, Anthony W. Purcell, Colin F. Spraggs, Jessica Whritenour, Dean J. Naisbitt

Research output: Contribution to journal › Review Article › Research › peer-review

20 Citations (Scopus)

Abstract

The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.

Original language	English
Pages (from-to)	239-259
Number of pages	21
Journal	Chemical Research in Toxicology
Volume	30
Issue number	1
DOIs	https://doi.org/10.1021/acs.chemrestox.6b00333
Publication status	Published - 17 Jan 2017

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10.1021/acs.chemrestox.6b00333

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Ogese, M. O., Ahmed, S., Alferivic, A., Betts, C. J., Dickinson, A., Faulkner, L., French, N., Gibson, A., Hirschfield, G. M., Kammüller, M., Meng, X., Martin, S. F., Musette, P., Norris, A., Pirmohamed, M., Park, B. K., Purcell, A. W., Spraggs, C. F., Whritenour, J., & Naisbitt, D. J. (2017). New Approaches to Investigate Drug-Induced Hypersensitivity. Chemical Research in Toxicology, 30(1), 239-259. https://doi.org/10.1021/acs.chemrestox.6b00333

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title = "New Approaches to Investigate Drug-Induced Hypersensitivity",

abstract = "The workshop on {"}New Approaches to Investigate Drug-Induced Hypersensitivity{"} was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.",

author = "Ogese, {Monday O.} and Shaheda Ahmed and Ana Alferivic and Betts, {Catherine J.} and Anne Dickinson and Lee Faulkner and Neil French and Andrew Gibson and Hirschfield, {Gideon M.} and Michael Kamm{\"u}ller and Xiaoli Meng and Martin, {Stefan F.} and Philippe Musette and Alan Norris and Munir Pirmohamed and Park, {B. Kevin} and Purcell, {Anthony W.} and Spraggs, {Colin F.} and Jessica Whritenour and Naisbitt, {Dean J.}",

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doi = "10.1021/acs.chemrestox.6b00333",

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Ogese, MO, Ahmed, S, Alferivic, A, Betts, CJ, Dickinson, A, Faulkner, L, French, N, Gibson, A, Hirschfield, GM, Kammüller, M, Meng, X, Martin, SF, Musette, P, Norris, A, Pirmohamed, M, Park, BK, Purcell, AW, Spraggs, CF, Whritenour, J & Naisbitt, DJ 2017, 'New Approaches to Investigate Drug-Induced Hypersensitivity', Chemical Research in Toxicology, vol. 30, no. 1, pp. 239-259. https://doi.org/10.1021/acs.chemrestox.6b00333

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AU - Ogese, Monday O.

AU - Ahmed, Shaheda

AU - Alferivic, Ana

AU - Betts, Catherine J.

AU - Dickinson, Anne

AU - Faulkner, Lee

AU - French, Neil

AU - Gibson, Andrew

AU - Hirschfield, Gideon M.

AU - Kammüller, Michael

AU - Meng, Xiaoli

AU - Martin, Stefan F.

AU - Musette, Philippe

AU - Norris, Alan

AU - Pirmohamed, Munir

AU - Park, B. Kevin

AU - Purcell, Anthony W.

AU - Spraggs, Colin F.

AU - Whritenour, Jessica

AU - Naisbitt, Dean J.

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AB - The workshop on "New Approaches to Investigate Drug-Induced Hypersensitivity" was held on June 5, 2014 at the Foresight Center, University of Liverpool. The aims of the workshop were to (1) discuss our current understanding of the genetic, clinical, and chemical basis of small molecule drug hypersensitivity, (2) highlight the current status of assays that might be developed to predict potential drug immunogenicity, and (3) identify the limitations, knowledge gaps, and challenges that limit the use of these assays and utilize the knowledge gained from the workshop to develop a pathway to establish new and improved assays that better predict drug-induced hypersensitivity reactions during the early stages of drug development. This perspective reviews the clinical and immunological bases of drug hypersensitivity and summarizes various experts' views on the different topics covered during the meeting.

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New Approaches to Investigate Drug-Induced Hypersensitivity

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New Approaches to Investigate Drug-Induced Hypersensitivity

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