New acoustic method for detecting upper airway obstruction in patients with sleep apnoea

Elaine Maria Stockx, Peter Camilleri, Elizabeth Michalina Skuza, Thomas Churchward, Julia Howes, Michael Ho, Timothy McDonald, Nick Freezer, Garun Stuart Hamilton, Malcolm Howard Wilkinson, Philip John Berger

Research output: Contribution to journalArticleResearchpeer-review

Abstract

This article investigates a new acoustic device to assess the behaviour of the upper airway in patients with OSA. Currently there is no simple non-invasive method to perform such measurements. As such this paper describes the device in probing the patency of the airway during sleep and increasing the efficiency of diagnosing OSA. BACKGROUND AND OBJECTIVE: OSA is a common disorder resulting in health and economic burdens. Currently identifying OSA in patients involves expensive techniques that require overnight studies in a laboratory setting with qualified staff. This paper tests a new acoustic device (AirwayClear (AC)) for assessing upper airway patency in human subjects with OSA. We hypothesize that obstructive apnoeas would be detected equally well with AC and polysomnography (PSG). METHODS: Twenty-three patients with severe OSA underwent an overnight CPAP titration study. We introduced pseudorandom noise (600-1200 Hz) using AC to the patient s nasal mask during 1 h of subtherapeutic CPAP. AC determined a measure of airway patency based on the level of pseudorandom noise reaching a sternal notch sensor. The ability of AC to detect obstructive respiratory events was compared with standard PSG. RESULTS: Three hundred and twenty-two obstructive events (obstructive and mixed apnoeas) were identified by PSG. AC scored 80 as complete obstructions and 16 as partial obstructions. Conversely, AC detected 281 complete obstructions. PSG recognized 84 as apnoeas and scored 11 as hypopnoeas. Of the 204 hypopnoeas identified with PSG, AC indicated the airway was partially or completely obstructed in 69 of patients. A Bland-Altman analysis for the apnoeas from the two measures showed a mean difference of 2.3 events/h and 95 confidence intervals of +/-15.5 events/h. CONCLUSIONS: We conclude that AC is able to track airway patency and to identify airway closure in patients with OSA.
Original languageEnglish
Pages (from-to)326 - 335
Number of pages10
JournalRespirology
Volume15
Issue number2
DOIs
Publication statusPublished - 2010

Cite this

Stockx, E. M., Camilleri, P., Skuza, E. M., Churchward, T., Howes, J., Ho, M., ... Berger, P. J. (2010). New acoustic method for detecting upper airway obstruction in patients with sleep apnoea. Respirology, 15(2), 326 - 335. https://doi.org/10.1111/j.1440-1843.2009.01689.x
Stockx, Elaine Maria ; Camilleri, Peter ; Skuza, Elizabeth Michalina ; Churchward, Thomas ; Howes, Julia ; Ho, Michael ; McDonald, Timothy ; Freezer, Nick ; Hamilton, Garun Stuart ; Wilkinson, Malcolm Howard ; Berger, Philip John. / New acoustic method for detecting upper airway obstruction in patients with sleep apnoea. In: Respirology. 2010 ; Vol. 15, No. 2. pp. 326 - 335.
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abstract = "This article investigates a new acoustic device to assess the behaviour of the upper airway in patients with OSA. Currently there is no simple non-invasive method to perform such measurements. As such this paper describes the device in probing the patency of the airway during sleep and increasing the efficiency of diagnosing OSA. BACKGROUND AND OBJECTIVE: OSA is a common disorder resulting in health and economic burdens. Currently identifying OSA in patients involves expensive techniques that require overnight studies in a laboratory setting with qualified staff. This paper tests a new acoustic device (AirwayClear (AC)) for assessing upper airway patency in human subjects with OSA. We hypothesize that obstructive apnoeas would be detected equally well with AC and polysomnography (PSG). METHODS: Twenty-three patients with severe OSA underwent an overnight CPAP titration study. We introduced pseudorandom noise (600-1200 Hz) using AC to the patient s nasal mask during 1 h of subtherapeutic CPAP. AC determined a measure of airway patency based on the level of pseudorandom noise reaching a sternal notch sensor. The ability of AC to detect obstructive respiratory events was compared with standard PSG. RESULTS: Three hundred and twenty-two obstructive events (obstructive and mixed apnoeas) were identified by PSG. AC scored 80 as complete obstructions and 16 as partial obstructions. Conversely, AC detected 281 complete obstructions. PSG recognized 84 as apnoeas and scored 11 as hypopnoeas. Of the 204 hypopnoeas identified with PSG, AC indicated the airway was partially or completely obstructed in 69 of patients. A Bland-Altman analysis for the apnoeas from the two measures showed a mean difference of 2.3 events/h and 95 confidence intervals of +/-15.5 events/h. CONCLUSIONS: We conclude that AC is able to track airway patency and to identify airway closure in patients with OSA.",
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Stockx, EM, Camilleri, P, Skuza, EM, Churchward, T, Howes, J, Ho, M, McDonald, T, Freezer, N, Hamilton, GS, Wilkinson, MH & Berger, PJ 2010, 'New acoustic method for detecting upper airway obstruction in patients with sleep apnoea' Respirology, vol. 15, no. 2, pp. 326 - 335. https://doi.org/10.1111/j.1440-1843.2009.01689.x

New acoustic method for detecting upper airway obstruction in patients with sleep apnoea. / Stockx, Elaine Maria; Camilleri, Peter; Skuza, Elizabeth Michalina; Churchward, Thomas; Howes, Julia; Ho, Michael; McDonald, Timothy; Freezer, Nick; Hamilton, Garun Stuart; Wilkinson, Malcolm Howard; Berger, Philip John.

In: Respirology, Vol. 15, No. 2, 2010, p. 326 - 335.

Research output: Contribution to journalArticleResearchpeer-review

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AU - Stockx, Elaine Maria

AU - Camilleri, Peter

AU - Skuza, Elizabeth Michalina

AU - Churchward, Thomas

AU - Howes, Julia

AU - Ho, Michael

AU - McDonald, Timothy

AU - Freezer, Nick

AU - Hamilton, Garun Stuart

AU - Wilkinson, Malcolm Howard

AU - Berger, Philip John

PY - 2010

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N2 - This article investigates a new acoustic device to assess the behaviour of the upper airway in patients with OSA. Currently there is no simple non-invasive method to perform such measurements. As such this paper describes the device in probing the patency of the airway during sleep and increasing the efficiency of diagnosing OSA. BACKGROUND AND OBJECTIVE: OSA is a common disorder resulting in health and economic burdens. Currently identifying OSA in patients involves expensive techniques that require overnight studies in a laboratory setting with qualified staff. This paper tests a new acoustic device (AirwayClear (AC)) for assessing upper airway patency in human subjects with OSA. We hypothesize that obstructive apnoeas would be detected equally well with AC and polysomnography (PSG). METHODS: Twenty-three patients with severe OSA underwent an overnight CPAP titration study. We introduced pseudorandom noise (600-1200 Hz) using AC to the patient s nasal mask during 1 h of subtherapeutic CPAP. AC determined a measure of airway patency based on the level of pseudorandom noise reaching a sternal notch sensor. The ability of AC to detect obstructive respiratory events was compared with standard PSG. RESULTS: Three hundred and twenty-two obstructive events (obstructive and mixed apnoeas) were identified by PSG. AC scored 80 as complete obstructions and 16 as partial obstructions. Conversely, AC detected 281 complete obstructions. PSG recognized 84 as apnoeas and scored 11 as hypopnoeas. Of the 204 hypopnoeas identified with PSG, AC indicated the airway was partially or completely obstructed in 69 of patients. A Bland-Altman analysis for the apnoeas from the two measures showed a mean difference of 2.3 events/h and 95 confidence intervals of +/-15.5 events/h. CONCLUSIONS: We conclude that AC is able to track airway patency and to identify airway closure in patients with OSA.

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