Neutrophils: important contributors to tumor progression and metastasis

Agnieszka Swierczak, Kellie A Mouchemore, John A Hamilton, Robin L Anderson

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69 Citations (Scopus)

Abstract

The presence of neutrophils in tumors has traditionally been considered to be indicative of a failed immune response against cancers. However, there is now evidence showing that neutrophils can promote tumor growth, and increasingly, the data support an active role for neutrophils in tumor progression to distant metastasis. Neutrophils have been implicated in promoting metastasis in cancer patients, where neutrophil numbers and neutrophil-related factors and functions have been associated with progressive disease. Nevertheless, the role of neutrophils in tumors, both at the primary and secondary sites, remains controversial, with some studies reporting their anti-tumor functions. This review will focus on the data demonstrating a role for neutrophils in both tumor growth and metastasis and will attempt to clarify the discrepancies in the literature.
Original languageEnglish
Pages (from-to)735 - 751
Number of pages17
JournalCancer and Metastasis Reviews
Volume34
Issue number4
DOIs
Publication statusPublished - 2015

Cite this

Swierczak, A., Mouchemore, K. A., Hamilton, J. A., & Anderson, R. L. (2015). Neutrophils: important contributors to tumor progression and metastasis. Cancer and Metastasis Reviews, 34(4), 735 - 751. https://doi.org/10.1007/s10555-015-9594-9