Abstract
In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils from naïve BALB/c mice were found to reduce numbers of culturable Yersinia pestis strain GB in suspension. A murine, BALB/c, intranasal model of pneumonic plague was used in conjunction with in vivo neutrophil ablation, using the GR-1 antibody. This treatment reduced neutrophil numbers without affecting other leukocyte numbers. Neutrophil ablated mice exhibited increased bacterial colonisation of the lung 24 h post infection. Furthermore, exposure of Y. pestis to human neutrophils resulted in a 5-fold reduction in the number of viable bacterial cells, whereas, PBMCs had no effect. Crown
Original language | English |
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Pages (from-to) | 331-335 |
Number of pages | 5 |
Journal | Microbes and Infection |
Volume | 12 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Apr 2010 |
Keywords
- Ablation
- ex vivo
- Innate immunity
- Intranasal
- Neutrophil
- Yersinia pestis