Neutrophils are important in early control of lung infection by Yersinia pestis

Thomas R. Laws; Martin S. Davey; Richard W. Titball; Roman Lukaszewski

doi:10.1016/j.micinf.2010.01.007

Neutrophils are important in early control of lung infection by Yersinia pestis

Thomas R. Laws, Martin S. Davey, Richard W. Titball, Roman Lukaszewski

Biochemistry & Molecular Biology

Research output: Contribution to journal › Article › Research › peer-review

32 Citations (Scopus)

Abstract

In this paper we evaluate the role of neutrophils in pneumonic plague. Splenic neutrophils from naïve BALB/c mice were found to reduce numbers of culturable Yersinia pestis strain GB in suspension. A murine, BALB/c, intranasal model of pneumonic plague was used in conjunction with in vivo neutrophil ablation, using the GR-1 antibody. This treatment reduced neutrophil numbers without affecting other leukocyte numbers. Neutrophil ablated mice exhibited increased bacterial colonisation of the lung 24 h post infection. Furthermore, exposure of Y. pestis to human neutrophils resulted in a 5-fold reduction in the number of viable bacterial cells, whereas, PBMCs had no effect. Crown

Original language	English
Pages (from-to)	331-335
Number of pages	5
Journal	Microbes and Infection
Volume	12
Issue number	4
DOIs	https://doi.org/10.1016/j.micinf.2010.01.007
Publication status	Published - 1 Apr 2010

Keywords

Ablation
ex vivo
Innate immunity
Intranasal
Neutrophil
Yersinia pestis

Access to Document

10.1016/j.micinf.2010.01.007

Link to publication in Scopus

Cite this

Laws, T. R., Davey, M. S., Titball, R. W., & Lukaszewski, R. (2010). Neutrophils are important in early control of lung infection by Yersinia pestis. Microbes and Infection, 12(4), 331-335. https://doi.org/10.1016/j.micinf.2010.01.007

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