Neutrophil–macrophage cooperation and its impact on tissue repair

Tiffany Bouchery, Nicola Harris

Research output: Contribution to journalReview ArticleOtherpeer-review

7 Citations (Scopus)

Abstract

Immune cells are rapidly recruited to a site of injury or infection. Although the importance of phagocytic immune cells in clearing bacteria has long been appreciated, the advent of technologies allowing more in-depth analysis of cellular function, such as intravital microscopy and the use of genetically modified animal models, has allowed much deeper insight into the complex roles of these cells play during tissue repair. Many immune cells contribute to the repair process; however, this review will concentrate on the involvement of the phagocytes, namely macrophages and neutrophils, with a particular focus on our more recent understanding of how interactions between these two cell types impact on the final outcome of tissue repair.

Original languageEnglish
Pages (from-to)289-298
Number of pages10
JournalImmunology and Cell Biology
Volume97
Issue number3
DOIs
Publication statusPublished - 1 Mar 2019

Keywords

  • Efferocytosis
  • IL-4
  • Injury
  • macrophages
  • neutrophil
  • type 2 immune response

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