Abstract
Neutrophilic dermatoses have primarily been classified based on their histological appearance
and many have overlapping associations with systemic diseases. This article provides a brief
overview of the two most common neutrophilic dermatoses, Sweet s syndrome and pyoderma
gangrenosum. The clinical presentation, systemic associations, histology, treatment and the
occurrence in the paediatric population of these entities are discussed. A clear understanding
of the pathogenesis of these conditions remains elusive. The concept of autoinflammation is
introduced, and how further investigation and knowledge of the pathways of the innate immune
system may lead to the potential reclassification of neutrophilic dermatoses and more targeted
treatment is discussed.
Original language | English |
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Pages (from-to) | 115 - 123 |
Number of pages | 9 |
Journal | Hong Kong Journal of Dermatology and Venereology |
Volume | 22 |
Issue number | 3 |
Publication status | Published - 2014 |