Neutrophil-mediated regulation of innate and adaptive immunity: The role of myeloperoxidase

Research output: Contribution to journalArticleOtherpeer-review

55 Citations (Scopus)

Abstract

Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.

Original languageEnglish
Article number2349817
Pages (from-to)1 - 11
Number of pages11
JournalJournal of Immunology Research
Volume2016
DOIs
Publication statusPublished - 2016

Cite this

@article{046a42389c2246c391f352615dcd1b53,
title = "Neutrophil-mediated regulation of innate and adaptive immunity: The role of myeloperoxidase",
abstract = "Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.",
author = "Dragana Odobasic and Kitching, {A. Richard} and Holdsworth, {Stephen R.}",
year = "2016",
doi = "10.1155/2016/2349817",
language = "English",
volume = "2016",
pages = "1 -- 11",
journal = "Journal of Immunology Research",
issn = "2314-8861",
publisher = "Hindawi Publishing Corporation",

}

Neutrophil-mediated regulation of innate and adaptive immunity : The role of myeloperoxidase. / Odobasic, Dragana; Kitching, A. Richard; Holdsworth, Stephen R.

In: Journal of Immunology Research, Vol. 2016, 2349817, 2016, p. 1 - 11.

Research output: Contribution to journalArticleOtherpeer-review

TY - JOUR

T1 - Neutrophil-mediated regulation of innate and adaptive immunity

T2 - The role of myeloperoxidase

AU - Odobasic, Dragana

AU - Kitching, A. Richard

AU - Holdsworth, Stephen R.

PY - 2016

Y1 - 2016

N2 - Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.

AB - Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.

UR - http://www.scopus.com/inward/record.url?scp=84958787507&partnerID=8YFLogxK

UR - https://www.hindawi.com/journals/jir/2016/2349817/

U2 - 10.1155/2016/2349817

DO - 10.1155/2016/2349817

M3 - Article

AN - SCOPUS:84958787507

VL - 2016

SP - 1

EP - 11

JO - Journal of Immunology Research

JF - Journal of Immunology Research

SN - 2314-8861

M1 - 2349817

ER -