Neutrophil-mediated regulation of innate and adaptive immunity: The role of myeloperoxidase

Dragana Odobasic, A. Richard Kitching, Stephen R. Holdsworth

Research output: Contribution to journalArticleOtherpeer-review

135 Citations (Scopus)


Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.

Original languageEnglish
Article number2349817
Pages (from-to)1 - 11
Number of pages11
JournalJournal of Immunology Research
Publication statusPublished - 2016

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