TY - JOUR
T1 - Neutrophil-mediated regulation of innate and adaptive immunity
T2 - The role of myeloperoxidase
AU - Odobasic, Dragana
AU - Kitching, A. Richard
AU - Holdsworth, Stephen R.
PY - 2016
Y1 - 2016
N2 - Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.
AB - Neutrophils are no longer seen as leukocytes with a sole function of being the essential first responders in the removal of pathogens at sites of infection. Being armed with numerous pro- and anti-inflammatory mediators, these phagocytes can also contribute to the development of various autoimmune diseases and can positively or negatively regulate the generation of adaptive immune responses. In this review, we will discuss how myeloperoxidase, the most abundant neutrophil granule protein, plays a key role in the various functions of neutrophils in innate and adaptive immunity.
UR - http://www.scopus.com/inward/record.url?scp=84958787507&partnerID=8YFLogxK
UR - https://www.hindawi.com/journals/jir/2016/2349817/
U2 - 10.1155/2016/2349817
DO - 10.1155/2016/2349817
M3 - Article
AN - SCOPUS:84958787507
SN - 2314-8861
VL - 2016
SP - 1
EP - 11
JO - Journal of Immunology Research
JF - Journal of Immunology Research
M1 - 2349817
ER -