Neutrophil extracellular traps (NETs) and the role of platelets in infection

Robert Keith Andrews, Jane Frances Arthur, Elizabeth Ellen Gardiner

Research output: Contribution to journalArticleResearchpeer-review

44 Citations (Scopus)

Abstract

In addition to playing a central role in normal haemostasis, platelets make important contributions to host inflammatory and immune responses to injury or infection. Under pathophysiological conditions where platelet function is not tightly controlled, platelets also play critical roles in pathogenic processes underlying cardiovascular disease, uncontrolled inflammation, coagulopathy and in tumour metastasis. Neutrophil extracellular traps (NETs) are webs of histone-modified nuclear material extruded from activated neutrophils during inflammatory responses and these degranulation events can be directly triggered by platelet/neutrophil engagement. Emerging research describes how NETs influence platelet function, particularly in the setting of infection and inflammation. Especially intriguing is the potential for platelet-driven coagulation to be modulated by NETs in plasma and interstitial spaces. These findings also reveal new perspectives related to improved therapy for venous thrombosis.
Original languageEnglish
Pages (from-to)659 - 665
Number of pages7
JournalThrombosis and Haemostasis
Volume112
Issue number4
DOIs
Publication statusPublished - 2014

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