Neutralizing antibody-based prevention of cell-associated HIV-1 infection

Matthew S. Parsons, Roger Le Grand, Stephen J. Kent

Research output: Contribution to journalReview ArticleOtherpeer-review

3 Citations (Scopus)

Abstract

Improved vaccine-mediated protection against HIV-1 requires a thorough understanding of the mode of HIV-1 transmission and how various immune responses control transmission. Cell-associated HIV-1 is infectious and contributes to HIV-1 transmission in humans. Non-human primate models of cell-associated SIV infection demonstrate that cell-associated SIV is more infectious than cell-free SIV. In a recently described chimeric simian–human immunodeficiency virus (SHIV) macaque model, it was demonstrated that an occult infection with cell-associated SHIV can be established that evades passive protection with a broadly neutralizing antibody (bnAb). Indeed, considerable in vitro data shows that bnAbs have less efficacy against cell-associated HIV-1 than cell-free HIV-1. Optimizing the protective capacity of immune responses such as bnAbs against cell-associated infections may be needed to maximize their protective efficacy.

Original languageEnglish
Article number333
Number of pages13
JournalViruses
Volume10
Issue number6
DOIs
Publication statusPublished - 18 Jun 2018

Keywords

  • Broadly neutralizing antibody
  • Cell-associated virus
  • HIV-1
  • Simian-human immunodeficiency virus

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