Neutralization epitopes of human rhinovirus type 2

G. Appleyard; S.M. Russell; B.E. Clarke; S.A.  Speller; R. Trowbridge; Jim Vadolas

doi:10.1099/0022-1317-71-6-1275

Neutralization epitopes of human rhinovirus type 2

G. Appleyard, S.M. Russell, B.E. Clarke, S.A. Speller, R. Trowbridge, Jim Vadolas

Research output: Contribution to journal › Article › Research › peer-review

Abstract

Fourteen neutralizing monoclonal antibodies recognizing human rhinovirus (HRV) type 2 have been used to select a total of 51 virus escape mutants. Cross-resistance analysis of the mutants, together with RNA sequencing and identification of amino acid substitutions, have revealed three neutralization sites on the virus surface. Two of these appear to correspond to the NIm-IA and NIm-II sites described for HRV-type 14, although there are also substantial differences. The third site has not been described previously

Original language	English
Pages (from-to)	1275-1282
Number of pages	8
Journal	Journal of General Virology
Volume	71
Issue number	6
DOIs	https://doi.org/10.1099/0022-1317-71-6-1275
Publication status	Published - 1 Jun 1990
Externally published	Yes

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Cite this

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abstract = "Fourteen neutralizing monoclonal antibodies recognizing human rhinovirus (HRV) type 2 have been used to select a total of 51 virus escape mutants. Cross-resistance analysis of the mutants, together with RNA sequencing and identification of amino acid substitutions, have revealed three neutralization sites on the virus surface. Two of these appear to correspond to the NIm-IA and NIm-II sites described for HRV-type 14, although there are also substantial differences. The third site has not been described previously",

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AU - Appleyard, G.

AU - Russell, S.M.

AU - Clarke, B.E.

AU - Speller, S.A.

AU - Trowbridge, R.

AU - Vadolas, Jim

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AB - Fourteen neutralizing monoclonal antibodies recognizing human rhinovirus (HRV) type 2 have been used to select a total of 51 virus escape mutants. Cross-resistance analysis of the mutants, together with RNA sequencing and identification of amino acid substitutions, have revealed three neutralization sites on the virus surface. Two of these appear to correspond to the NIm-IA and NIm-II sites described for HRV-type 14, although there are also substantial differences. The third site has not been described previously

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DO - 10.1099/0022-1317-71-6-1275

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