TY - JOUR
T1 - Neuropsychological and neurophysiological predictors and consequences of cannabis and illicit substance use during neurodevelopment
T2 - a systematic review of longitudinal studies
AU - Debenham, Jennifer
AU - Birrell, Louise
AU - Champion, Katrina
AU - Lees, Briana
AU - Yücel, Murat
AU - Newton, Nicola
N1 - Funding Information:
JD is supported by the Matilda Centre for Research in Mental Health and Substance Use, University of Sydney, Sydney, NSW, Australia. LB is supported by an Australian Rotary Health Bruce Edwards Postdoctoral Fellowship. KC is funded by an Australian National Health and Medical Research Council Early Career Fellowship. BL is funded by the National Health and Medical Research Council GNT1169377. MY is funded by an Australian National Health and Medical Research Council Principal Research Fellowship. NN is funded by an Australian National Health and Medical Research Council Career Development Fellowship. The funding organisations played no role in the study design, data collection, extraction, interpretation, or write up of this manuscript. The corresponding author had final responsibility of the results and publications of this study.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/8
Y1 - 2021/8
N2 - Adolescence and early adulthood are crucial periods of neurodevelopment characterised by functional, structural, and cognitive maturation, which helps prepare young people for adulthood. This systematic review of longitudinal studies aims to delineate neural predictors from neural consequences of cannabis and illicit substance use, as well as investigate the potential for the developing brain (at ages 10–25 years) to recover after damage. Five databases were searched to yield a total of 38 eligible studies, with some assessing multiple outcome techniques, including 22 neuroimaging, two neurophysiological, and 22 neuropsychological findings. High-quality evidence suggested that delayed or irregular neurodevelopment in executive functioning, particularly emotional perception, might predispose young people to higher frequency substance use. There was evidence of functional, structural, and cognitive deficits proceeding substance use, with harm potentially dependent on the frequency of use and recovery potentially dependent on the duration of use. Identifying aberrant neurodevelopment in young people is crucial for preventing substance use-related harm.
AB - Adolescence and early adulthood are crucial periods of neurodevelopment characterised by functional, structural, and cognitive maturation, which helps prepare young people for adulthood. This systematic review of longitudinal studies aims to delineate neural predictors from neural consequences of cannabis and illicit substance use, as well as investigate the potential for the developing brain (at ages 10–25 years) to recover after damage. Five databases were searched to yield a total of 38 eligible studies, with some assessing multiple outcome techniques, including 22 neuroimaging, two neurophysiological, and 22 neuropsychological findings. High-quality evidence suggested that delayed or irregular neurodevelopment in executive functioning, particularly emotional perception, might predispose young people to higher frequency substance use. There was evidence of functional, structural, and cognitive deficits proceeding substance use, with harm potentially dependent on the frequency of use and recovery potentially dependent on the duration of use. Identifying aberrant neurodevelopment in young people is crucial for preventing substance use-related harm.
UR - http://www.scopus.com/inward/record.url?scp=85107022478&partnerID=8YFLogxK
U2 - 10.1016/S2352-4642(21)00051-1
DO - 10.1016/S2352-4642(21)00051-1
M3 - Review Article
C2 - 33991473
AN - SCOPUS:85107022478
SN - 2352-4642
VL - 5
SP - 589
EP - 604
JO - The Lancet Child & Adolescent Health
JF - The Lancet Child & Adolescent Health
IS - 8
ER -