TY - JOUR
T1 - Neuroprotective and antioxidant constituents from Curcuma zedoaria Rhizomes
AU - Hamdi, Omer Abdalla Ahmed
AU - Ye, Lo Jia
AU - Kamarudin, Muhamad Noor Alfarizal
AU - Hazni, Hazrina
AU - Paydar, Mohammadjavad
AU - Looi, Chung Yeng
AU - Shilpi, Jamil A.
AU - Kadir, Habsah Abdul
AU - Awang, Khalijah
N1 - Publisher Copyright:
© 2015 ACG Publications. All rights reserved.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/1/4
Y1 - 2015/1/4
N2 - This study investigates the effect of phytochemical constituents from medicinally important plant Curcuma zedoaria (Christm.) Rosc., on hydrogen peroxide induced oxidative stress in mouse neuroblastoma-rat glioma hybridoma cells NG108-15. Phytochemical investigation of C. zedoaria rhizomes resulted in the isolation of nine sesquiterpenes (germacrone 1, dehydrocurdione 2, curcumenol 3, isoprocurcumenol 5, curcumenone 6, procurcumenol 7, zerumbone epoxide 8, zederone 9 and gweicurculactone 10) and one labdane diterpene (zerumin A 4). Curcumenol (3) and dehydrocurdione (2) showed 100% protection of the NG108-15 cells at the concentrations of 4 and 10μM, respectively. Procurcumenol (7), isoprocurcumenol (5), zerumbone epoxide (8), zerumin A (4) and germacrone (1) showed moderate activity (80-90% protection). In the oxygen radical antioxidant capacity (ORAC) assay, all the test compounds showed strong antioxidant activity except curcumenol (3) which showed moderate antioxidant activity, as compared to the reference standard quercetin.
AB - This study investigates the effect of phytochemical constituents from medicinally important plant Curcuma zedoaria (Christm.) Rosc., on hydrogen peroxide induced oxidative stress in mouse neuroblastoma-rat glioma hybridoma cells NG108-15. Phytochemical investigation of C. zedoaria rhizomes resulted in the isolation of nine sesquiterpenes (germacrone 1, dehydrocurdione 2, curcumenol 3, isoprocurcumenol 5, curcumenone 6, procurcumenol 7, zerumbone epoxide 8, zederone 9 and gweicurculactone 10) and one labdane diterpene (zerumin A 4). Curcumenol (3) and dehydrocurdione (2) showed 100% protection of the NG108-15 cells at the concentrations of 4 and 10μM, respectively. Procurcumenol (7), isoprocurcumenol (5), zerumbone epoxide (8), zerumin A (4) and germacrone (1) showed moderate activity (80-90% protection). In the oxygen radical antioxidant capacity (ORAC) assay, all the test compounds showed strong antioxidant activity except curcumenol (3) which showed moderate antioxidant activity, as compared to the reference standard quercetin.
KW - Curcumenol
KW - Dehydrocurdion
KW - NG108-15 cells
KW - ORAC assay
KW - Zerumbone epoxide
UR - http://www.scopus.com/inward/record.url?scp=84928163436&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:84928163436
VL - 9
SP - 349
EP - 355
JO - Records of Natural Products
JF - Records of Natural Products
SN - 1307-6167
IS - 3
ER -