Neuroprotective and antioxidant constituents from Curcuma zedoaria Rhizomes

Omer Abdalla Ahmed Hamdi; Lo Jia Ye; Muhamad Noor Alfarizal Kamarudin; Hazrina Hazni; Mohammadjavad Paydar; Chung Yeng Looi; Jamil A. Shilpi; Habsah Abdul Kadir; Khalijah Awang

Neuroprotective and antioxidant constituents from Curcuma zedoaria Rhizomes

Omer Abdalla Ahmed Hamdi, Lo Jia Ye, Muhamad Noor Alfarizal Kamarudin, Hazrina Hazni, Mohammadjavad Paydar, Chung Yeng Looi, Jamil A. Shilpi, Habsah Abdul Kadir, Khalijah Awang

Research output: Contribution to journal › Article › Research › peer-review

22 Citations (Scopus)

Abstract

This study investigates the effect of phytochemical constituents from medicinally important plant Curcuma zedoaria (Christm.) Rosc., on hydrogen peroxide induced oxidative stress in mouse neuroblastoma-rat glioma hybridoma cells NG108-15. Phytochemical investigation of C. zedoaria rhizomes resulted in the isolation of nine sesquiterpenes (germacrone 1, dehydrocurdione 2, curcumenol 3, isoprocurcumenol 5, curcumenone 6, procurcumenol 7, zerumbone epoxide 8, zederone 9 and gweicurculactone 10) and one labdane diterpene (zerumin A 4). Curcumenol (3) and dehydrocurdione (2) showed 100% protection of the NG108-15 cells at the concentrations of 4 and 10μM, respectively. Procurcumenol (7), isoprocurcumenol (5), zerumbone epoxide (8), zerumin A (4) and germacrone (1) showed moderate activity (80-90% protection). In the oxygen radical antioxidant capacity (ORAC) assay, all the test compounds showed strong antioxidant activity except curcumenol (3) which showed moderate antioxidant activity, as compared to the reference standard quercetin.

Original language	English
Pages (from-to)	349-355
Number of pages	7
Journal	Records of Natural Products
Volume	9
Issue number	3
Publication status	Published - 4 Jan 2015
Externally published	Yes

Keywords

Curcumenol
Dehydrocurdion
NG108-15 cells
ORAC assay
Zerumbone epoxide

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@article{9772f0c66304439ea31d18369089eb22,

title = "Neuroprotective and antioxidant constituents from Curcuma zedoaria Rhizomes",

abstract = "This study investigates the effect of phytochemical constituents from medicinally important plant Curcuma zedoaria (Christm.) Rosc., on hydrogen peroxide induced oxidative stress in mouse neuroblastoma-rat glioma hybridoma cells NG108-15. Phytochemical investigation of C. zedoaria rhizomes resulted in the isolation of nine sesquiterpenes (germacrone 1, dehydrocurdione 2, curcumenol 3, isoprocurcumenol 5, curcumenone 6, procurcumenol 7, zerumbone epoxide 8, zederone 9 and gweicurculactone 10) and one labdane diterpene (zerumin A 4). Curcumenol (3) and dehydrocurdione (2) showed 100% protection of the NG108-15 cells at the concentrations of 4 and 10μM, respectively. Procurcumenol (7), isoprocurcumenol (5), zerumbone epoxide (8), zerumin A (4) and germacrone (1) showed moderate activity (80-90% protection). In the oxygen radical antioxidant capacity (ORAC) assay, all the test compounds showed strong antioxidant activity except curcumenol (3) which showed moderate antioxidant activity, as compared to the reference standard quercetin.",

keywords = "Curcumenol, Dehydrocurdion, NG108-15 cells, ORAC assay, Zerumbone epoxide",

author = "Hamdi, {Omer Abdalla Ahmed} and Ye, {Lo Jia} and Kamarudin, {Muhamad Noor Alfarizal} and Hazrina Hazni and Mohammadjavad Paydar and Looi, {Chung Yeng} and Shilpi, {Jamil A.} and Kadir, {Habsah Abdul} and Khalijah Awang",

year = "2015",

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language = "English",

volume = "9",

pages = "349--355",

journal = "Records of Natural Products",

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Neuroprotective and antioxidant constituents from Curcuma zedoaria Rhizomes. / Hamdi, Omer Abdalla Ahmed; Ye, Lo Jia; Kamarudin, Muhamad Noor Alfarizal; Hazni, Hazrina; Paydar, Mohammadjavad; Looi, Chung Yeng; Shilpi, Jamil A.; Kadir, Habsah Abdul; Awang, Khalijah.

In: Records of Natural Products, Vol. 9, No. 3, 04.01.2015, p. 349-355.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Neuroprotective and antioxidant constituents from Curcuma zedoaria Rhizomes

AU - Hamdi, Omer Abdalla Ahmed

AU - Ye, Lo Jia

AU - Kamarudin, Muhamad Noor Alfarizal

AU - Hazni, Hazrina

AU - Paydar, Mohammadjavad

AU - Looi, Chung Yeng

AU - Shilpi, Jamil A.

AU - Kadir, Habsah Abdul

AU - Awang, Khalijah

PY - 2015/1/4

Y1 - 2015/1/4

N2 - This study investigates the effect of phytochemical constituents from medicinally important plant Curcuma zedoaria (Christm.) Rosc., on hydrogen peroxide induced oxidative stress in mouse neuroblastoma-rat glioma hybridoma cells NG108-15. Phytochemical investigation of C. zedoaria rhizomes resulted in the isolation of nine sesquiterpenes (germacrone 1, dehydrocurdione 2, curcumenol 3, isoprocurcumenol 5, curcumenone 6, procurcumenol 7, zerumbone epoxide 8, zederone 9 and gweicurculactone 10) and one labdane diterpene (zerumin A 4). Curcumenol (3) and dehydrocurdione (2) showed 100% protection of the NG108-15 cells at the concentrations of 4 and 10μM, respectively. Procurcumenol (7), isoprocurcumenol (5), zerumbone epoxide (8), zerumin A (4) and germacrone (1) showed moderate activity (80-90% protection). In the oxygen radical antioxidant capacity (ORAC) assay, all the test compounds showed strong antioxidant activity except curcumenol (3) which showed moderate antioxidant activity, as compared to the reference standard quercetin.

AB - This study investigates the effect of phytochemical constituents from medicinally important plant Curcuma zedoaria (Christm.) Rosc., on hydrogen peroxide induced oxidative stress in mouse neuroblastoma-rat glioma hybridoma cells NG108-15. Phytochemical investigation of C. zedoaria rhizomes resulted in the isolation of nine sesquiterpenes (germacrone 1, dehydrocurdione 2, curcumenol 3, isoprocurcumenol 5, curcumenone 6, procurcumenol 7, zerumbone epoxide 8, zederone 9 and gweicurculactone 10) and one labdane diterpene (zerumin A 4). Curcumenol (3) and dehydrocurdione (2) showed 100% protection of the NG108-15 cells at the concentrations of 4 and 10μM, respectively. Procurcumenol (7), isoprocurcumenol (5), zerumbone epoxide (8), zerumin A (4) and germacrone (1) showed moderate activity (80-90% protection). In the oxygen radical antioxidant capacity (ORAC) assay, all the test compounds showed strong antioxidant activity except curcumenol (3) which showed moderate antioxidant activity, as compared to the reference standard quercetin.

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KW - ORAC assay

KW - Zerumbone epoxide

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