Neuropathology and functional deficits in a model of birth asphyxia in the precocial spiny mouse (Acomys cahirinus)

Lisa Cathleen Hutton, Udani Ratnayake, Amy Shields, David William Walker

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Birth asphyxia can result in sensory impairment, learning and memory deficits without gross brain injury and severe motor deficits. We developed a model of birth asphyxia resulting in mild neurological injury and cognitive impairment using a long-gestation species with precocial fetal development. Spiny mice (Acomys cahirinus) underwent caesarean-section delivery or 7.5 min of asphyxia at 37 days gestational age (term is 39 days). Brain histology was examined at 1 and 7 days of age, and behaviour was evaluated to 28 days of age. Asphyxiated offspring showed significant impairment in non-spatial memory and learning tasks, accompanied by central nervous system inflammation and increased apoptotic cell death but without the presence of large necrotic or cystic lesions.
Original languageEnglish
Pages (from-to)523 - 535
Number of pages13
JournalDevelopmental Neuroscience
Volume31
Issue number6
DOIs
Publication statusPublished - 2009

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