Abstract
Using stereological analysis of NeuN-stained sections, we investigated neuronal density and number of neurons per column throughout the marmoset cortex. Estimates of mean neuronal density encompassed a greater than 3-fold range, from >150 000 neurons/mm3 in the primary visual cortex to ~50 000 neurons/mm3 in the piriform complex. There was a trend for density to decrease from posterior to anterior cortex, but also local gradients, which resulted in a complex pattern; for example, in frontal, auditory, and somatosensory cortex neuronal density tended to increase towards anterior areas. Anterior cingulate, motor, premotor, insular, and ventral temporal areas were characterized by relatively low neuronal densities. Analysis across the depth of the cortex revealed greater laminar variation of neuronal density in occipital, parietal, and inferior temporal areas, in comparison with other regions. Moreover, differences between areas were more pronounced in the supragranular layers than in infragranular layers. Calculations of the number of neurons per unit column revealed a pattern that was distinct from that of neuronal density, including local peaks in the posterior parietal, superior temporal, precuneate, frontopolar, and temporopolar regions. These results suggest that neuronal distribution in adult cortex result from a complex interaction of developmental/ evolutionary determinants and functional requirements.
| Original language | English |
|---|---|
| Pages (from-to) | 3836-3863 |
| Number of pages | 28 |
| Journal | Cerebral Cortex |
| Volume | 29 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 14 Aug 2019 |
Keywords
- Callithrix jacchus
- cytoarchitecture
- NeuN
- neuronal density
- primate
Cite this
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Neuronal Distribution Across the Cerebral Cortex of the Marmoset Monkey (Callithrix jacchus). / Atapour, Nafiseh; Majka, Piotr; Wolkowicz, Ianina H.; Malamanova, Daria; Worthy, Katrina H.; Rosa, Marcello G.P.
In: Cerebral Cortex, Vol. 29, No. 9, 14.08.2019, p. 3836-3863.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Neuronal Distribution Across the Cerebral Cortex of the Marmoset Monkey (Callithrix jacchus)
AU - Atapour, Nafiseh
AU - Majka, Piotr
AU - Wolkowicz, Ianina H.
AU - Malamanova, Daria
AU - Worthy, Katrina H.
AU - Rosa, Marcello G.P.
PY - 2019/8/14
Y1 - 2019/8/14
N2 - Using stereological analysis of NeuN-stained sections, we investigated neuronal density and number of neurons per column throughout the marmoset cortex. Estimates of mean neuronal density encompassed a greater than 3-fold range, from >150 000 neurons/mm3 in the primary visual cortex to ~50 000 neurons/mm3 in the piriform complex. There was a trend for density to decrease from posterior to anterior cortex, but also local gradients, which resulted in a complex pattern; for example, in frontal, auditory, and somatosensory cortex neuronal density tended to increase towards anterior areas. Anterior cingulate, motor, premotor, insular, and ventral temporal areas were characterized by relatively low neuronal densities. Analysis across the depth of the cortex revealed greater laminar variation of neuronal density in occipital, parietal, and inferior temporal areas, in comparison with other regions. Moreover, differences between areas were more pronounced in the supragranular layers than in infragranular layers. Calculations of the number of neurons per unit column revealed a pattern that was distinct from that of neuronal density, including local peaks in the posterior parietal, superior temporal, precuneate, frontopolar, and temporopolar regions. These results suggest that neuronal distribution in adult cortex result from a complex interaction of developmental/ evolutionary determinants and functional requirements.
AB - Using stereological analysis of NeuN-stained sections, we investigated neuronal density and number of neurons per column throughout the marmoset cortex. Estimates of mean neuronal density encompassed a greater than 3-fold range, from >150 000 neurons/mm3 in the primary visual cortex to ~50 000 neurons/mm3 in the piriform complex. There was a trend for density to decrease from posterior to anterior cortex, but also local gradients, which resulted in a complex pattern; for example, in frontal, auditory, and somatosensory cortex neuronal density tended to increase towards anterior areas. Anterior cingulate, motor, premotor, insular, and ventral temporal areas were characterized by relatively low neuronal densities. Analysis across the depth of the cortex revealed greater laminar variation of neuronal density in occipital, parietal, and inferior temporal areas, in comparison with other regions. Moreover, differences between areas were more pronounced in the supragranular layers than in infragranular layers. Calculations of the number of neurons per unit column revealed a pattern that was distinct from that of neuronal density, including local peaks in the posterior parietal, superior temporal, precuneate, frontopolar, and temporopolar regions. These results suggest that neuronal distribution in adult cortex result from a complex interaction of developmental/ evolutionary determinants and functional requirements.
KW - Callithrix jacchus
KW - cytoarchitecture
KW - NeuN
KW - neuronal density
KW - primate
UR - http://www.scopus.com/inward/record.url?scp=85065327096&partnerID=8YFLogxK
U2 - 10.1093/cercor/bhy263
DO - 10.1093/cercor/bhy263
M3 - Article
VL - 29
SP - 3836
EP - 3863
JO - Cerebral Cortex
JF - Cerebral Cortex
SN - 1047-3211
IS - 9
ER -