Projects per year
Abstract
Using stereological analysis of NeuN-stained sections, we investigated neuronal density and number of neurons per column throughout the marmoset cortex. Estimates of mean neuronal density encompassed a greater than 3-fold range, from >150 000 neurons/mm3 in the primary visual cortex to ~50 000 neurons/mm3 in the piriform complex. There was a trend for density to decrease from posterior to anterior cortex, but also local gradients, which resulted in a complex pattern; for example, in frontal, auditory, and somatosensory cortex neuronal density tended to increase towards anterior areas. Anterior cingulate, motor, premotor, insular, and ventral temporal areas were characterized by relatively low neuronal densities. Analysis across the depth of the cortex revealed greater laminar variation of neuronal density in occipital, parietal, and inferior temporal areas, in comparison with other regions. Moreover, differences between areas were more pronounced in the supragranular layers than in infragranular layers. Calculations of the number of neurons per unit column revealed a pattern that was distinct from that of neuronal density, including local peaks in the posterior parietal, superior temporal, precuneate, frontopolar, and temporopolar regions. These results suggest that neuronal distribution in adult cortex result from a complex interaction of developmental/ evolutionary determinants and functional requirements.
Original language | English |
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Pages (from-to) | 3836-3863 |
Number of pages | 28 |
Journal | Cerebral Cortex |
Volume | 29 |
Issue number | 9 |
DOIs | |
Publication status | Published - 14 Aug 2019 |
Keywords
- Callithrix jacchus
- cytoarchitecture
- NeuN
- neuronal density
- primate
Projects
- 2 Finished
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ARC Centre of Excellence for Integrative Brain Function
Egan, G., Rosa, M., Lowery, A., Stuart, G., Arabzadeh, E., Skafidas, E., Ibbotson, M., Petrou, S., Paxinos, G., Mattingley, J., Garrido, M., Sah, P., Robinson, P. A., Martin, P., Grunert, U., Tanaka, K., Mitra, P., Johnson, G., Diamond, M., Margrie, T., Leopold, D., Movshon, J., Markram, H., Victor, J., Hill, S. & Jirsa, V.
Australian National University , ETH Zurich, Australian Research Council (ARC), Karolinska Institute, QIMR Berghofer Medical Research Institute, Ecole Polytechnique Federale de Lausanne (Swiss Federal Institute of Technology in Lausanne) , Monash University, University of Melbourne, University of New South Wales, University of Queensland , University of Sydney, Monash University – Internal University Contribution, National Institutes of Health (United States), Cornell University, New York University, MRC National Institute for Medical Research, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Duke University, Cold Spring Harbor Laboratory, RIKEN
25/06/14 → 31/12/21
Project: Research
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Understanding complex networks of connections in the primate cerebral cortex
Rosa, M. & Mitra, P.
Australian Research Council (ARC), Monash University
2/01/14 → 31/12/16
Project: Research
Equipment
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eResearch Centre
Paul Bonnington (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility
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Histology Platform
Camilla Cohen (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
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MASSIVE
Paul Bonnington (Manager) & Slava Kitaeff (Manager)
Office of the Vice-Provost (Research and Research Infrastructure)Facility/equipment: Facility