Neuromyelitis optica (Devic's disease) in a patient with syphilis

Robert A. Wilcox, James Burrow, Mark Slee, Jamie Craig, Dominic Thyagarajan

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11 Citations (Scopus)


The patient initially presented with bilateral optic neuritis and periventricular cranial MRI abnormalities in the context of syphilis. Blood was positive but cerebrospinal fluid testing was negative for specific syphilis markers and he was oligoclonal cerebrospinal fluid (CSF) band negative. He initially responded well to penicillin and corticosteriod treatment, but went on to develop the clinical syndrome of neuromyelitis optica (NMO). Testing for the presence of the serum autoantibody for aqua-porin-4 was negative. This patient appears to represent another case of post-infectious NMO. Possible pathogenesis of this post-syphilis NMO syndrome in the patient is discussed.

Original languageEnglish
Pages (from-to)268-271
Number of pages4
JournalMultiple Sclerosis
Issue number2
Publication statusPublished - Mar 2008
Externally publishedYes


  • Aquaporin-4 antibody
  • Devic's disease
  • Neuromyelitis optica
  • NMO
  • Syphilis

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