Neuromodulation of Attention

Alexander Thiele, Mark A. Bellgrove

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Attention is critical to high-level cognition and attention deficits are a hallmark of neurologic and neuropsychiatric disorders. Although years of research indicates that distinct neuromodulators influence attentional control, a mechanistic account that traverses levels of analysis (cells, circuits, behavior) is missing. However, such an account is critical to guide the development of next-generation pharmacotherapies aimed at forestalling or remediating the global burden associated with disorders of attention. Here, we summarize current neuroscientific understanding of how attention affects single neurons and networks of neurons. We then review key results that have informed our understanding of how neuromodulation shapes these neuron and network properties and thereby enables the appropriate allocation of attention to relevant external or internal events. Finally, we highlight areas where we believe hypotheses can be formulated and tackled experimentally in the near future, thereby critically increasing our mechanistic understanding of how attention is implemented at the cellular and network levels.
LanguageEnglish
Pages769-785
Number of pages17
JournalNeuron
Volume97
Issue number4
DOIs
StatePublished - 21 Feb 2018

Keywords

  • Attention
  • Pharmacology
  • Top-down
  • neuromodulators
  • Attractor networks
  • Population coding

Cite this

Thiele, Alexander ; Bellgrove, Mark A./ Neuromodulation of Attention. In: Neuron. 2018 ; Vol. 97, No. 4. pp. 769-785
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Thiele, A & Bellgrove, MA 2018, 'Neuromodulation of Attention' Neuron, vol. 97, no. 4, pp. 769-785. DOI: 10.1016/j.neuron.2018.01.008

Neuromodulation of Attention. / Thiele, Alexander; Bellgrove, Mark A.

In: Neuron, Vol. 97, No. 4, 21.02.2018, p. 769-785.

Research output: Contribution to journalReview ArticleResearchpeer-review

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Thiele A, Bellgrove MA. Neuromodulation of Attention. Neuron. 2018 Feb 21;97(4):769-785. Available from, DOI: 10.1016/j.neuron.2018.01.008