Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 607 - 618 |
| Number of pages | 12 |
| Journal | Revista de Neurologia |
| Volume | 53 |
| Issue number | 10 |
| Publication status | Published - 2011 |
| Externally published | Yes |
Cite this
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Neurological tests for functional outcome assessment in rodent models of ischaemic stroke. / Zarruk, Juan; Garcia-Yebenes, Isaac; Romera, Victor; Ballesteros, Ivan; Moraga, Ana; Cuartero, Maria; Hurtado, Olivia; Sobrado, Monica; Pradillo, Jesus; Fernandez-Lopez, David; Serena, Joaquin; Zakhem, Margie; Moro, Maria; Lizasoain, Ignacio.
In: Revista de Neurologia, Vol. 53, No. 10, 2011, p. 607 - 618.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Neurological tests for functional outcome assessment in rodent models of ischaemic stroke
AU - Zarruk, Juan
AU - Garcia-Yebenes, Isaac
AU - Romera, Victor
AU - Ballesteros, Ivan
AU - Moraga, Ana
AU - Cuartero, Maria
AU - Hurtado, Olivia
AU - Sobrado, Monica
AU - Pradillo, Jesus
AU - Fernandez-Lopez, David
AU - Serena, Joaquin
AU - Zakhem, Margie
AU - Moro, Maria
AU - Lizasoain, Ignacio
PY - 2011
Y1 - 2011
N2 - A critical aspect in all models is the assessment of the final outcome of the modelling procedure. In the case of a focal ischaemic brain injury, apart from the determination of the size of the lesion, another valuable tool is the evaluation of the final functional deficit. Indeed, ischaemic damage leads to the appearance of different degrees of sensoriomotor and cognitive impairments, which may yield useful information on location and size of the lesion and on the efficacy of neuroprotective treatments after the acute injury. In addition, the magnitude of these impairments may also be useful to predict final outcome and to evaluate neuro-restorative therapies in a long-term scenario. To this aim, a wide range of tests has been developed which allow the quantification of all these neurological symptoms. This review intends to compile the most useful behavioural tests designed to assess neurological symptoms in studies of focal experimental cerebral ischemia in rodents induced by middle cerebral artery occlusion, the most commonly used model of ischaemic stroke.
AB - A critical aspect in all models is the assessment of the final outcome of the modelling procedure. In the case of a focal ischaemic brain injury, apart from the determination of the size of the lesion, another valuable tool is the evaluation of the final functional deficit. Indeed, ischaemic damage leads to the appearance of different degrees of sensoriomotor and cognitive impairments, which may yield useful information on location and size of the lesion and on the efficacy of neuroprotective treatments after the acute injury. In addition, the magnitude of these impairments may also be useful to predict final outcome and to evaluate neuro-restorative therapies in a long-term scenario. To this aim, a wide range of tests has been developed which allow the quantification of all these neurological symptoms. This review intends to compile the most useful behavioural tests designed to assess neurological symptoms in studies of focal experimental cerebral ischemia in rodents induced by middle cerebral artery occlusion, the most commonly used model of ischaemic stroke.
UR - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=22052176
M3 - Article
VL - 53
SP - 607
EP - 618
JO - Revista de Neurologia
JF - Revista de Neurologia
SN - 0210-0010
IS - 10
ER -