Neuroinflammatory processes in the pathogenesis of Alzheimer's disease

Mastura Monif, David A. Williams

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

Abstract

Alzheimer's disease (AD), which is characterized by a progressive decline in memory and other cognitive functions, is the most common dementia in today's society. The incidence of this condition is on the rise, and currently there are no effective treatment modalities. Microglia-mediated neuroinflammation is thought to be associated with the initiation and progression of a number of neurodegenerative conditions including AD. Chronic activation of microglia exposes the central nervous system to various cytokines, chemokines, complement proteins, reactive oxygen species, all of which could have neurotoxic consequences when present in excess. In the neuroinflammatory foci of Alzheimer's the neurofibrillary tangles and Aß aggregates are associated with activated microglia and increased levels of a purinergic P2X7 receptor (P2X7R). We have shown that up-regulation of P2X7R is sufficient to drive the activation and proliferation of microglia, as well as enhancing the release of various inflammatory mediators. This chapter will highlight some of the recent findings in the field of Alzheimer's research of particular reference to the neuroinflammatory hypothesis. The contribution to AD progression of immunomodulatory responses such as microglial activation, and the role of P2X7R, will be discussed.

Original languageEnglish
Title of host publicationNeuroinflammation
Subtitle of host publicationPathogenesis, Mechanisms and Management
PublisherNova Science Publishers
Chapter2
Pages19-46
Number of pages28
ISBN (Print)9781619424623
Publication statusPublished - 1 Oct 2012
Externally publishedYes

Cite this

Monif, M., & Williams, D. A. (2012). Neuroinflammatory processes in the pathogenesis of Alzheimer's disease. In Neuroinflammation: Pathogenesis, Mechanisms and Management (pp. 19-46). Nova Science Publishers.
Monif, Mastura ; Williams, David A. / Neuroinflammatory processes in the pathogenesis of Alzheimer's disease. Neuroinflammation: Pathogenesis, Mechanisms and Management. Nova Science Publishers, 2012. pp. 19-46
@inbook{23fdb3329e074301a4b28efffedaabcd,
title = "Neuroinflammatory processes in the pathogenesis of Alzheimer's disease",
abstract = "Alzheimer's disease (AD), which is characterized by a progressive decline in memory and other cognitive functions, is the most common dementia in today's society. The incidence of this condition is on the rise, and currently there are no effective treatment modalities. Microglia-mediated neuroinflammation is thought to be associated with the initiation and progression of a number of neurodegenerative conditions including AD. Chronic activation of microglia exposes the central nervous system to various cytokines, chemokines, complement proteins, reactive oxygen species, all of which could have neurotoxic consequences when present in excess. In the neuroinflammatory foci of Alzheimer's the neurofibrillary tangles and A{\ss} aggregates are associated with activated microglia and increased levels of a purinergic P2X7 receptor (P2X7R). We have shown that up-regulation of P2X7R is sufficient to drive the activation and proliferation of microglia, as well as enhancing the release of various inflammatory mediators. This chapter will highlight some of the recent findings in the field of Alzheimer's research of particular reference to the neuroinflammatory hypothesis. The contribution to AD progression of immunomodulatory responses such as microglial activation, and the role of P2X7R, will be discussed.",
author = "Mastura Monif and Williams, {David A.}",
year = "2012",
month = "10",
day = "1",
language = "English",
isbn = "9781619424623",
pages = "19--46",
booktitle = "Neuroinflammation",
publisher = "Nova Science Publishers",
address = "United States of America",

}

Monif, M & Williams, DA 2012, Neuroinflammatory processes in the pathogenesis of Alzheimer's disease. in Neuroinflammation: Pathogenesis, Mechanisms and Management. Nova Science Publishers, pp. 19-46.

Neuroinflammatory processes in the pathogenesis of Alzheimer's disease. / Monif, Mastura; Williams, David A.

Neuroinflammation: Pathogenesis, Mechanisms and Management. Nova Science Publishers, 2012. p. 19-46.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

TY - CHAP

T1 - Neuroinflammatory processes in the pathogenesis of Alzheimer's disease

AU - Monif, Mastura

AU - Williams, David A.

PY - 2012/10/1

Y1 - 2012/10/1

N2 - Alzheimer's disease (AD), which is characterized by a progressive decline in memory and other cognitive functions, is the most common dementia in today's society. The incidence of this condition is on the rise, and currently there are no effective treatment modalities. Microglia-mediated neuroinflammation is thought to be associated with the initiation and progression of a number of neurodegenerative conditions including AD. Chronic activation of microglia exposes the central nervous system to various cytokines, chemokines, complement proteins, reactive oxygen species, all of which could have neurotoxic consequences when present in excess. In the neuroinflammatory foci of Alzheimer's the neurofibrillary tangles and Aß aggregates are associated with activated microglia and increased levels of a purinergic P2X7 receptor (P2X7R). We have shown that up-regulation of P2X7R is sufficient to drive the activation and proliferation of microglia, as well as enhancing the release of various inflammatory mediators. This chapter will highlight some of the recent findings in the field of Alzheimer's research of particular reference to the neuroinflammatory hypothesis. The contribution to AD progression of immunomodulatory responses such as microglial activation, and the role of P2X7R, will be discussed.

AB - Alzheimer's disease (AD), which is characterized by a progressive decline in memory and other cognitive functions, is the most common dementia in today's society. The incidence of this condition is on the rise, and currently there are no effective treatment modalities. Microglia-mediated neuroinflammation is thought to be associated with the initiation and progression of a number of neurodegenerative conditions including AD. Chronic activation of microglia exposes the central nervous system to various cytokines, chemokines, complement proteins, reactive oxygen species, all of which could have neurotoxic consequences when present in excess. In the neuroinflammatory foci of Alzheimer's the neurofibrillary tangles and Aß aggregates are associated with activated microglia and increased levels of a purinergic P2X7 receptor (P2X7R). We have shown that up-regulation of P2X7R is sufficient to drive the activation and proliferation of microglia, as well as enhancing the release of various inflammatory mediators. This chapter will highlight some of the recent findings in the field of Alzheimer's research of particular reference to the neuroinflammatory hypothesis. The contribution to AD progression of immunomodulatory responses such as microglial activation, and the role of P2X7R, will be discussed.

UR - http://www.scopus.com/inward/record.url?scp=84895303768&partnerID=8YFLogxK

M3 - Chapter (Book)

SN - 9781619424623

SP - 19

EP - 46

BT - Neuroinflammation

PB - Nova Science Publishers

ER -

Monif M, Williams DA. Neuroinflammatory processes in the pathogenesis of Alzheimer's disease. In Neuroinflammation: Pathogenesis, Mechanisms and Management. Nova Science Publishers. 2012. p. 19-46