Neuroinflammation, Type 2 Diabetes, and Dementia

Connie H.Y. Wong, Brooke J. Wanrooy, David G. Bruce

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

1 Citation (Scopus)

Abstract

Neuroinflammation is a strong candidate to explain, at least in part, the increased dementia risk in type 2 diabetes (T2D). Currently, this hypothesis is largely circumstantial, based on clinical and experimental findings indicating that neuroinflammation has a more important role in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD) than previously considered and evidence that T2D is a disorder with a strong inflammatory component that may promote neuroinflammation. A number of animal models have been studied that indicate that T2D or related pathophysiological processes are able to exacerbate AD-related processes via inflammatory pathways. Advances in positron emission tomography with radioligands that quantify neuroinflammation provide an opportunity to study whether chronic peripheral inflammatory states seen in T2D lead to increased neuroinflammation and contribute to cognitive decline in this common age-related condition.

Original languageEnglish
Title of host publicationType 2 Diabetes and Dementia
EditorsVelandai Srikanth, Zoe Arvanitakis
Place of PublicationLondon
PublisherAcademic Press
Pages195-209
Number of pages15
ISBN (Electronic)9780128096949
ISBN (Print)9780128094549
DOIs
Publication statusPublished - 6 Mar 2018

Keywords

  • Dementia
  • Inflammation
  • Neuroinflammation
  • Type 2 diabetes

Cite this

Wong, C. H. Y., Wanrooy, B. J., & Bruce, D. G. (2018). Neuroinflammation, Type 2 Diabetes, and Dementia. In V. Srikanth, & Z. Arvanitakis (Eds.), Type 2 Diabetes and Dementia (pp. 195-209). London: Academic Press. https://doi.org/10.1016/B978-0-12-809454-9.00010-X
Wong, Connie H.Y. ; Wanrooy, Brooke J. ; Bruce, David G. / Neuroinflammation, Type 2 Diabetes, and Dementia. Type 2 Diabetes and Dementia. editor / Velandai Srikanth ; Zoe Arvanitakis. London : Academic Press, 2018. pp. 195-209
@inbook{acdc013a37e046319fa1f21d3b4b214f,
title = "Neuroinflammation, Type 2 Diabetes, and Dementia",
abstract = "Neuroinflammation is a strong candidate to explain, at least in part, the increased dementia risk in type 2 diabetes (T2D). Currently, this hypothesis is largely circumstantial, based on clinical and experimental findings indicating that neuroinflammation has a more important role in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD) than previously considered and evidence that T2D is a disorder with a strong inflammatory component that may promote neuroinflammation. A number of animal models have been studied that indicate that T2D or related pathophysiological processes are able to exacerbate AD-related processes via inflammatory pathways. Advances in positron emission tomography with radioligands that quantify neuroinflammation provide an opportunity to study whether chronic peripheral inflammatory states seen in T2D lead to increased neuroinflammation and contribute to cognitive decline in this common age-related condition.",
keywords = "Dementia, Inflammation, Neuroinflammation, Type 2 diabetes",
author = "Wong, {Connie H.Y.} and Wanrooy, {Brooke J.} and Bruce, {David G.}",
year = "2018",
month = "3",
day = "6",
doi = "10.1016/B978-0-12-809454-9.00010-X",
language = "English",
isbn = "9780128094549",
pages = "195--209",
editor = "Srikanth, {Velandai } and Arvanitakis, {Zoe }",
booktitle = "Type 2 Diabetes and Dementia",
publisher = "Academic Press",
address = "United States of America",

}

Wong, CHY, Wanrooy, BJ & Bruce, DG 2018, Neuroinflammation, Type 2 Diabetes, and Dementia. in V Srikanth & Z Arvanitakis (eds), Type 2 Diabetes and Dementia. Academic Press, London, pp. 195-209. https://doi.org/10.1016/B978-0-12-809454-9.00010-X

Neuroinflammation, Type 2 Diabetes, and Dementia. / Wong, Connie H.Y.; Wanrooy, Brooke J.; Bruce, David G.

Type 2 Diabetes and Dementia. ed. / Velandai Srikanth; Zoe Arvanitakis. London : Academic Press, 2018. p. 195-209.

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Otherpeer-review

TY - CHAP

T1 - Neuroinflammation, Type 2 Diabetes, and Dementia

AU - Wong, Connie H.Y.

AU - Wanrooy, Brooke J.

AU - Bruce, David G.

PY - 2018/3/6

Y1 - 2018/3/6

N2 - Neuroinflammation is a strong candidate to explain, at least in part, the increased dementia risk in type 2 diabetes (T2D). Currently, this hypothesis is largely circumstantial, based on clinical and experimental findings indicating that neuroinflammation has a more important role in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD) than previously considered and evidence that T2D is a disorder with a strong inflammatory component that may promote neuroinflammation. A number of animal models have been studied that indicate that T2D or related pathophysiological processes are able to exacerbate AD-related processes via inflammatory pathways. Advances in positron emission tomography with radioligands that quantify neuroinflammation provide an opportunity to study whether chronic peripheral inflammatory states seen in T2D lead to increased neuroinflammation and contribute to cognitive decline in this common age-related condition.

AB - Neuroinflammation is a strong candidate to explain, at least in part, the increased dementia risk in type 2 diabetes (T2D). Currently, this hypothesis is largely circumstantial, based on clinical and experimental findings indicating that neuroinflammation has a more important role in the pathogenesis of neurodegenerative disorders including Alzheimer's disease (AD) than previously considered and evidence that T2D is a disorder with a strong inflammatory component that may promote neuroinflammation. A number of animal models have been studied that indicate that T2D or related pathophysiological processes are able to exacerbate AD-related processes via inflammatory pathways. Advances in positron emission tomography with radioligands that quantify neuroinflammation provide an opportunity to study whether chronic peripheral inflammatory states seen in T2D lead to increased neuroinflammation and contribute to cognitive decline in this common age-related condition.

KW - Dementia

KW - Inflammation

KW - Neuroinflammation

KW - Type 2 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85047310578&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-809454-9.00010-X

DO - 10.1016/B978-0-12-809454-9.00010-X

M3 - Chapter (Book)

SN - 9780128094549

SP - 195

EP - 209

BT - Type 2 Diabetes and Dementia

A2 - Srikanth, Velandai

A2 - Arvanitakis, Zoe

PB - Academic Press

CY - London

ER -

Wong CHY, Wanrooy BJ, Bruce DG. Neuroinflammation, Type 2 Diabetes, and Dementia. In Srikanth V, Arvanitakis Z, editors, Type 2 Diabetes and Dementia. London: Academic Press. 2018. p. 195-209 https://doi.org/10.1016/B978-0-12-809454-9.00010-X