Neuroinflammation and copper in Alzheimer's disease

Xin Yi Choo, Lobna Alukaidey, Anthony R. White, Alexandra Grubman

Research output: Contribution to journalReview ArticleResearchpeer-review

31 Citations (Scopus)

Abstract

Inflammation is the innate immune response to infection or tissue damage. Initiation of proinflammatory cascades in the central nervous system (CNS) occurs through recognition of danger associated molecular patterns by cognate immune receptors expressed on inflammatory cells and leads to rapid responses to remove the danger stimulus. The presence of activated microglia and astrocytes in the vicinity of amyloid plaques in the brains of Alzheimer's disease (AD) patients and mouse models implicates inflammation as a contributor to AD pathogenesis. Activated microglia play a critical role in amyloid clearance, but chronic deregulation of CNS inflammatory pathways results in secretion of neurotoxic mediators that ultimately contribute to neurodegeneration in AD. Copper (Cu) homeostasis is profoundly affected in AD, and accumulated extracellular Cu drives Aβ aggregation, while intracellular Cu deficiency limits bioavailable Cu required for CNS functions. This review presents an overview of inflammatory events that occur in AD in response to Aβ and highlights recent advances on the role of Cu in modulation of beneficial and detrimental inflammatory responses in AD.
Original languageEnglish
Article number145345
Number of pages12
JournalInternational Journal of Alzheimer's Disease
Volume2013
DOIs
Publication statusPublished - 2013
Externally publishedYes

Cite this

Choo, Xin Yi ; Alukaidey, Lobna ; White, Anthony R. ; Grubman, Alexandra. / Neuroinflammation and copper in Alzheimer's disease. In: International Journal of Alzheimer's Disease. 2013 ; Vol. 2013.
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Neuroinflammation and copper in Alzheimer's disease. / Choo, Xin Yi; Alukaidey, Lobna; White, Anthony R.; Grubman, Alexandra.

In: International Journal of Alzheimer's Disease, Vol. 2013, 145345, 2013.

Research output: Contribution to journalReview ArticleResearchpeer-review

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