Neuroimaging and its Relevance to Understanding Pathways Linking Diabetes and Cognitive Dysfunction

Chris Moran, Richard Beare, Thanh Phan, Sergio Starkstein, David Bruce, Mizrahi Romina, Velandai Srikanth

Research output: Contribution to journalReview ArticleResearchpeer-review

17 Citations (Scopus)

Abstract

Diabetes mellitus is associated with an elevated risk of cognitive impairment and dementia. Cerebrovascular disease and neurodegeneration are two major pathways that may explain the effect of diabetes on the brain and therefore deserve investigation. Neuroimaging provides an effective way to investigate the contribution of these pathways in vivo, guiding further mechanistic research and providing biomarkers for clinical correlation or interventional studies. In this paper, we present a narrative review of the state of play with neuroimaging evidence in studies of people with diabetes mellitus, how these data are useful in understanding mechanistic links between diabetes and brain impairment, and possible ways that the field may develop in the future.

Original languageEnglish
Pages (from-to)405-419
Number of pages15
JournalJournal of Alzheimer's Disease
Volume59
Issue number2
DOIs
Publication statusPublished - 2017

Keywords

  • Alzheimer's disease
  • dementia
  • diabetes
  • neuroimaging

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