Projects per year
Abstract
The metabotropic glutamate (mGlu) receptor family is a potential therapeutic target for multiple central nervous system (CNS) disorders. However, aspects of mGlu receptor signaling and their role in neural pathways remain to be fully elucidated. Novel subtype selective allosteric modulators have revealed new roles for mGlu receptors in brain health and disease, as well as expanding on previously underappreciated aspects of mGlu signaling such as biased agonism and modulation. Recent advances have improved our understanding of mGlu receptor function. Harnessing these new insights to inform drug discovery programs has the potential to lead to the design and discovery of mGlu allosteric modulators that specifically drive glutamatergic activity toward therapeutically beneficial effects and avoid on-target adverse effect liability.
Original language | English |
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Pages (from-to) | 49-55 |
Number of pages | 7 |
Journal | Current Opinion in Pharmacology |
Volume | 32 |
DOIs | |
Publication status | Published - 1 Feb 2017 |
Projects
- 2 Finished
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Biased allosteric modulators of metabotropic glutamate receptors: novel therapeutic targets for CNS disorders
Gregory, K. (Primary Chief Investigator (PCI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/15 → 31/12/18
Project: Research
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Allosteric modulation and biased signalling at the calcium-sensing receptor
Christopoulos, A. (Primary Chief Investigator (PCI)), Conigrave, A. (Chief Investigator (CI)) & Leach, K. (Chief Investigator (CI))
National Health and Medical Research Council (NHMRC) (Australia)
1/01/12 → 31/12/14
Project: Research