TY - JOUR
T1 - Neurobiological findings in early phase schizophrenia
AU - Copolov, David
AU - Velakoulis, Dennis
AU - McGorry, Pat
AU - Carina Mallard, Mallard
AU - Yung, Alison
AU - Rees, Sandra
AU - Jackson, Graeme
AU - Rehn, Alison
AU - Brewer, Warrick
AU - Pantelis, Chris
PY - 2000/3/1
Y1 - 2000/3/1
N2 - This paper summarises the available information on MRI-determined hippocampal morphometry in first-episode patients as an illustration of the value and interpretation of findings in the neurobiology of early phase schizophrenia. We report a thin slice (1.5 mm) study of 32 first episode and 39 high risk patients which demonstrated significantly smaller hippocampi (right -9%, left -11%) in first episode patients that were of a similar magnitude to those found in chronic patients (right -10%, left -11%) but non-significant volume reductions in high risk individuals, including the 15 subjects who subsequently developed psychoses. Consideration is given to the implications of these findings, including the possible role of early and later neurodevelopmental influences. We present animal data showing that chronic placental insufficiency, as elicited by uterine artery ligation can give rise to substantial reduction (31%) in hippocampal volumes and reflect on other potentially relevant pathophysiological mechanisms, including those that may occur during the early phases of psychotic illnesses, including their prodromes. Greater attention needs to be paid to the study of early phase psychosis in order to obtain a clearer understanding of the nature and time course of neurobiological changes associated with it. Although there is a growing literature on first episode psychosis, there is a striking dearth of information on the neurobiology of the prodrome. Copyright (C) 2000 Elsevier Science, B.V.
AB - This paper summarises the available information on MRI-determined hippocampal morphometry in first-episode patients as an illustration of the value and interpretation of findings in the neurobiology of early phase schizophrenia. We report a thin slice (1.5 mm) study of 32 first episode and 39 high risk patients which demonstrated significantly smaller hippocampi (right -9%, left -11%) in first episode patients that were of a similar magnitude to those found in chronic patients (right -10%, left -11%) but non-significant volume reductions in high risk individuals, including the 15 subjects who subsequently developed psychoses. Consideration is given to the implications of these findings, including the possible role of early and later neurodevelopmental influences. We present animal data showing that chronic placental insufficiency, as elicited by uterine artery ligation can give rise to substantial reduction (31%) in hippocampal volumes and reflect on other potentially relevant pathophysiological mechanisms, including those that may occur during the early phases of psychotic illnesses, including their prodromes. Greater attention needs to be paid to the study of early phase psychosis in order to obtain a clearer understanding of the nature and time course of neurobiological changes associated with it. Although there is a growing literature on first episode psychosis, there is a striking dearth of information on the neurobiology of the prodrome. Copyright (C) 2000 Elsevier Science, B.V.
KW - First episode
KW - High risk
KW - Hippocampus
KW - Placental insufficiency
KW - Schizophrenia
KW - Uterine ligation
UR - http://www.scopus.com/inward/record.url?scp=0034093658&partnerID=8YFLogxK
U2 - 10.1016/S0165-0173(99)00033-8
DO - 10.1016/S0165-0173(99)00033-8
M3 - Article
C2 - 10719144
AN - SCOPUS:0034093658
SN - 0165-0173
VL - 31
SP - 157
EP - 165
JO - Brain Research Reviews
JF - Brain Research Reviews
IS - 2-3
ER -