Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm

Alicia J. Spittle, Jennifer M. Walsh, Cody Potter, Emma Mcinnes, Joy E. Olsen, Katherine J. Lee, Peter J Anderson, Lex W. Doyle, Jeanie L Y Cheong

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Aim: To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT). Method: Two-hundred and one infants born MLPT (born 32–36+6wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean. The relationships between neurobehaviour at term and Bayley-III cognitive, language, and motor scales at 2 years were examined using linear regression. Results: Increased odds for cognitive delay were associated with suboptimal HNNE total scores (odds ratio [OR] 2.66; 95% confidence interval [CI] 1.14–6.23, p=0.020) and suboptimal NNNS excitability (OR 3.01; 95% CI 1.33–6.82, p=0.008) and lethargy (OR 4.05; 95% CI 1.75–9.31, p=0.001) scores. Suboptimal lethargy scores on the NNNS were associated with increased odds of language (OR 5.64; 95% CI 1.33–23.85, p=0.019) and motor delay (OR: 6.86; 95% CI 1.64–28.71, p=0.08). Interpretation: Suboptimal performance on specific aspects of newborn neurobehavioural assessments is associated with neurodevelopmental delay at 2 years in children born MLPT.

Original languageEnglish
Pages (from-to)207-215
Number of pages9
JournalDevelopmental Medicine and Child Neurology
Volume59
Issue number2
DOIs
Publication statusPublished - Feb 2017
Externally publishedYes

Cite this

Spittle, Alicia J. ; Walsh, Jennifer M. ; Potter, Cody ; Mcinnes, Emma ; Olsen, Joy E. ; Lee, Katherine J. ; Anderson, Peter J ; Doyle, Lex W. ; Cheong, Jeanie L Y. / Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm. In: Developmental Medicine and Child Neurology. 2017 ; Vol. 59, No. 2. pp. 207-215.
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abstract = "Aim: To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT). Method: Two-hundred and one infants born MLPT (born 32–36+6wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean. The relationships between neurobehaviour at term and Bayley-III cognitive, language, and motor scales at 2 years were examined using linear regression. Results: Increased odds for cognitive delay were associated with suboptimal HNNE total scores (odds ratio [OR] 2.66; 95{\%} confidence interval [CI] 1.14–6.23, p=0.020) and suboptimal NNNS excitability (OR 3.01; 95{\%} CI 1.33–6.82, p=0.008) and lethargy (OR 4.05; 95{\%} CI 1.75–9.31, p=0.001) scores. Suboptimal lethargy scores on the NNNS were associated with increased odds of language (OR 5.64; 95{\%} CI 1.33–23.85, p=0.019) and motor delay (OR: 6.86; 95{\%} CI 1.64–28.71, p=0.08). Interpretation: Suboptimal performance on specific aspects of newborn neurobehavioural assessments is associated with neurodevelopmental delay at 2 years in children born MLPT.",
author = "Spittle, {Alicia J.} and Walsh, {Jennifer M.} and Cody Potter and Emma Mcinnes and Olsen, {Joy E.} and Lee, {Katherine J.} and Anderson, {Peter J} and Doyle, {Lex W.} and Cheong, {Jeanie L Y}",
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Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm. / Spittle, Alicia J.; Walsh, Jennifer M.; Potter, Cody; Mcinnes, Emma; Olsen, Joy E.; Lee, Katherine J.; Anderson, Peter J; Doyle, Lex W.; Cheong, Jeanie L Y.

In: Developmental Medicine and Child Neurology, Vol. 59, No. 2, 02.2017, p. 207-215.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Neurobehaviour at term-equivalent age and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm

AU - Spittle, Alicia J.

AU - Walsh, Jennifer M.

AU - Potter, Cody

AU - Mcinnes, Emma

AU - Olsen, Joy E.

AU - Lee, Katherine J.

AU - Anderson, Peter J

AU - Doyle, Lex W.

AU - Cheong, Jeanie L Y

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N2 - Aim: To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT). Method: Two-hundred and one infants born MLPT (born 32–36+6wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean. The relationships between neurobehaviour at term and Bayley-III cognitive, language, and motor scales at 2 years were examined using linear regression. Results: Increased odds for cognitive delay were associated with suboptimal HNNE total scores (odds ratio [OR] 2.66; 95% confidence interval [CI] 1.14–6.23, p=0.020) and suboptimal NNNS excitability (OR 3.01; 95% CI 1.33–6.82, p=0.008) and lethargy (OR 4.05; 95% CI 1.75–9.31, p=0.001) scores. Suboptimal lethargy scores on the NNNS were associated with increased odds of language (OR 5.64; 95% CI 1.33–23.85, p=0.019) and motor delay (OR: 6.86; 95% CI 1.64–28.71, p=0.08). Interpretation: Suboptimal performance on specific aspects of newborn neurobehavioural assessments is associated with neurodevelopmental delay at 2 years in children born MLPT.

AB - Aim: To examine the association between newborn neurobehavioural assessments and neurodevelopmental outcomes at 2 years in infants born moderate-to-late preterm (MLPT). Method: Two-hundred and one infants born MLPT (born 32–36+6wks' gestation) were assessed with the Hammersmith Neonatal Neurological Examination (HNNE) and NICU Network Neurobehavioral Scale (NNNS), with suboptimal performance defined as scores lower than the 10th centile. Development was assessed at 2 years corrected age with the Bayley Scales of Infant and Toddler Development 3rd Edition, with delay defined as scores less than 1 standard deviation (SD) below the mean. The relationships between neurobehaviour at term and Bayley-III cognitive, language, and motor scales at 2 years were examined using linear regression. Results: Increased odds for cognitive delay were associated with suboptimal HNNE total scores (odds ratio [OR] 2.66; 95% confidence interval [CI] 1.14–6.23, p=0.020) and suboptimal NNNS excitability (OR 3.01; 95% CI 1.33–6.82, p=0.008) and lethargy (OR 4.05; 95% CI 1.75–9.31, p=0.001) scores. Suboptimal lethargy scores on the NNNS were associated with increased odds of language (OR 5.64; 95% CI 1.33–23.85, p=0.019) and motor delay (OR: 6.86; 95% CI 1.64–28.71, p=0.08). Interpretation: Suboptimal performance on specific aspects of newborn neurobehavioural assessments is associated with neurodevelopmental delay at 2 years in children born MLPT.

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DO - 10.1111/dmcn.13297

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