Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia

C. A. Bousman; V. Cropley; P. Klauser; J. L. Hess; A. Pereira; R. Idrizi; J. Bruggemann; M. S. Mostaid; R. Lenroot; T. W. Weickert; S. J. Glatt; I. P. Everall; S. Sundram; A. Zalesky; C. S. Weickert; C. Pantelis

doi:10.1017/S0033291717002173

Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia

C. A. Bousman, V. Cropley, P. Klauser, J. L. Hess, A. Pereira, R. Idrizi, J. Bruggemann, M. S. Mostaid, R. Lenroot, T. W. Weickert, S. J. Glatt, I. P. Everall, S. Sundram, A. Zalesky, C. S. Weickert, C. Pantelis

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Abstract

Background Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been associated with psychosis transition. However, the neurobiological changes associated with these SNPs remain unclear. We aimed to determine what relationship these two SNPs have on lateral ventricular volume and white matter integrity, as abnormalities in these brain structures are some of the most consistent in schizophrenia. Methods Structural (n = 370) and diffusion (n = 465) magnetic resonance imaging data were obtained from affected and unaffected individuals predominantly of European descent. The SNPs rs4281084, rs12155594, and their combined allelic load were examined for their effects on lateral ventricular volume, fractional anisotropy (FA) as well as axial (AD) and radial (RD) diffusivity. Additional exploratory analyses assessed NRG1 effects on gray matter volume, cortical thickness, and surface area throughout the brain. Results Individuals with a schizophrenia age of onset

Original language	English
Pages (from-to)	801-809
Number of pages	9
Journal	Psychological Medicine
Volume	48
Issue number	5
DOIs	https://doi.org/10.1017/S0033291717002173
Publication status	Published - 1 Apr 2018

Keywords

Fractional anisotropy
lateral ventricles
neuregulin-1
neuroimaging
polymorphism

Access to Document

10.1017/S0033291717002173

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Cite this

Bousman, C. A., Cropley, V., Klauser, P., Hess, J. L., Pereira, A., Idrizi, R., Bruggemann, J., Mostaid, M. S., Lenroot, R., Weickert, T. W., Glatt, S. J., Everall, I. P., Sundram, S., Zalesky, A., Weickert, C. S., & Pantelis, C. (2018). Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia. Psychological Medicine, 48(5), 801-809. https://doi.org/10.1017/S0033291717002173

Bousman, C. A. ; Cropley, V. ; Klauser, P. ; Hess, J. L. ; Pereira, A. ; Idrizi, R. ; Bruggemann, J. ; Mostaid, M. S. ; Lenroot, R. ; Weickert, T. W. ; Glatt, S. J. ; Everall, I. P. ; Sundram, S. ; Zalesky, A. ; Weickert, C. S. ; Pantelis, C. / Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia. In: Psychological Medicine. 2018 ; Vol. 48, No. 5. pp. 801-809.

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title = "Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia",

abstract = "Background Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been associated with psychosis transition. However, the neurobiological changes associated with these SNPs remain unclear. We aimed to determine what relationship these two SNPs have on lateral ventricular volume and white matter integrity, as abnormalities in these brain structures are some of the most consistent in schizophrenia. Methods Structural (n = 370) and diffusion (n = 465) magnetic resonance imaging data were obtained from affected and unaffected individuals predominantly of European descent. The SNPs rs4281084, rs12155594, and their combined allelic load were examined for their effects on lateral ventricular volume, fractional anisotropy (FA) as well as axial (AD) and radial (RD) diffusivity. Additional exploratory analyses assessed NRG1 effects on gray matter volume, cortical thickness, and surface area throughout the brain. Results Individuals with a schizophrenia age of onset",

keywords = "Fractional anisotropy, lateral ventricles, neuregulin-1, neuroimaging, polymorphism",

author = "Bousman, {C. A.} and V. Cropley and P. Klauser and Hess, {J. L.} and A. Pereira and R. Idrizi and J. Bruggemann and Mostaid, {M. S.} and R. Lenroot and Weickert, {T. W.} and Glatt, {S. J.} and Everall, {I. P.} and S. Sundram and A. Zalesky and Weickert, {C. S.} and C. Pantelis",

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Bousman, CA, Cropley, V, Klauser, P, Hess, JL, Pereira, A, Idrizi, R, Bruggemann, J, Mostaid, MS, Lenroot, R, Weickert, TW, Glatt, SJ, Everall, IP, Sundram, S, Zalesky, A, Weickert, CS & Pantelis, C 2018, 'Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia', Psychological Medicine, vol. 48, no. 5, pp. 801-809. https://doi.org/10.1017/S0033291717002173

Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia. / Bousman, C. A.; Cropley, V.; Klauser, P.; Hess, J. L.; Pereira, A.; Idrizi, R.; Bruggemann, J.; Mostaid, M. S.; Lenroot, R.; Weickert, T. W.; Glatt, S. J.; Everall, I. P.; Sundram, S.; Zalesky, A.; Weickert, C. S.; Pantelis, C.

In: Psychological Medicine, Vol. 48, No. 5, 01.04.2018, p. 801-809.

Research output: Contribution to journal › Article › Research › peer-review

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T1 - Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia

AU - Bousman, C. A.

AU - Cropley, V.

AU - Klauser, P.

AU - Hess, J. L.

AU - Pereira, A.

AU - Idrizi, R.

AU - Bruggemann, J.

AU - Mostaid, M. S.

AU - Lenroot, R.

AU - Weickert, T. W.

AU - Glatt, S. J.

AU - Everall, I. P.

AU - Sundram, S.

AU - Zalesky, A.

AU - Weickert, C. S.

AU - Pantelis, C.

PY - 2018/4/1

Y1 - 2018/4/1

N2 - Background Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been associated with psychosis transition. However, the neurobiological changes associated with these SNPs remain unclear. We aimed to determine what relationship these two SNPs have on lateral ventricular volume and white matter integrity, as abnormalities in these brain structures are some of the most consistent in schizophrenia. Methods Structural (n = 370) and diffusion (n = 465) magnetic resonance imaging data were obtained from affected and unaffected individuals predominantly of European descent. The SNPs rs4281084, rs12155594, and their combined allelic load were examined for their effects on lateral ventricular volume, fractional anisotropy (FA) as well as axial (AD) and radial (RD) diffusivity. Additional exploratory analyses assessed NRG1 effects on gray matter volume, cortical thickness, and surface area throughout the brain. Results Individuals with a schizophrenia age of onset

AB - Background Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been associated with psychosis transition. However, the neurobiological changes associated with these SNPs remain unclear. We aimed to determine what relationship these two SNPs have on lateral ventricular volume and white matter integrity, as abnormalities in these brain structures are some of the most consistent in schizophrenia. Methods Structural (n = 370) and diffusion (n = 465) magnetic resonance imaging data were obtained from affected and unaffected individuals predominantly of European descent. The SNPs rs4281084, rs12155594, and their combined allelic load were examined for their effects on lateral ventricular volume, fractional anisotropy (FA) as well as axial (AD) and radial (RD) diffusivity. Additional exploratory analyses assessed NRG1 effects on gray matter volume, cortical thickness, and surface area throughout the brain. Results Individuals with a schizophrenia age of onset

KW - Fractional anisotropy

KW - lateral ventricles

KW - neuregulin-1

KW - neuroimaging

KW - polymorphism

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