Neuregulin-1 (NRG1) polymorphisms linked with psychosis transition are associated with enlarged lateral ventricles and white matter disruption in schizophrenia

C. A. Bousman, V. Cropley, P. Klauser, J. L. Hess, A. Pereira, R. Idrizi, J. Bruggemann, M. S. Mostaid, R. Lenroot, T. W. Weickert, S. J. Glatt, I. P. Everall, S. Sundram, A. Zalesky, C. S. Weickert, C. Pantelis

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Background Two single-nucleotide polymorphisms (SNPs) (rs4281084 and rs12155594) within the neuregulin-1 (NRG1) gene have been associated with psychosis transition. However, the neurobiological changes associated with these SNPs remain unclear. We aimed to determine what relationship these two SNPs have on lateral ventricular volume and white matter integrity, as abnormalities in these brain structures are some of the most consistent in schizophrenia. Methods Structural (n = 370) and diffusion (n = 465) magnetic resonance imaging data were obtained from affected and unaffected individuals predominantly of European descent. The SNPs rs4281084, rs12155594, and their combined allelic load were examined for their effects on lateral ventricular volume, fractional anisotropy (FA) as well as axial (AD) and radial (RD) diffusivity. Additional exploratory analyses assessed NRG1 effects on gray matter volume, cortical thickness, and surface area throughout the brain. Results Individuals with a schizophrenia age of onset

Original languageEnglish
Pages (from-to)801-809
Number of pages9
JournalPsychological Medicine
Issue number5
Publication statusPublished - 1 Apr 2018


  • Fractional anisotropy
  • lateral ventricles
  • neuregulin-1
  • neuroimaging
  • polymorphism

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