Neuraxial block, death and serious cardiovascular morbidity in the POISE trial

Kate Leslie, Paul S Myles, Philip J Devereaux, Elizabeth Jane Williamson, Purnima Rao-Melancini, Andrew Benjamin Forbes, Shouchun Xu, Pierre Foex, Janice Pogue, Maribel Arrieta, Gregory Bryson, James Paul, Michael Paech, Richard Merchant, Peter Choi, Neal H Badner, Philip Peyton, John William Sear, Homer Yang

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63 Citations (Scopus)

Abstract

BackgroundThis post hoc analysis aimed to determine whether neuraxial block was associated with a composite of cardiovascular death, non-fatal myocardial infarction (MI) and non-fatal cardiac arrest within 30 days of randomization in POISE trial patients.MethodsA total of 8351 non-cardiac surgical patients at high risk of cardiovascular complications were randomized to ?-blocker or placebo. Neuraxial block was defined as spinal, lumbar or thoracic epidural anaesthesia. Logistic regression, with weighting using estimated propensity scores, was used to determine the association between neuraxial block and primary and secondary outcomes.ResultsNeuraxial block was associated with an increased risk of the primary outcome [287 (7.3 ) vs 229 (5.7 ); odds ratio (OR), 1.24; 95 confidence interval (CI), 1.02-1.49; P=0.03] and MI [230 (5.9 ) vs 177 (4.4 ); OR, 1.32; 95 CI, 1.07-1.64; P=0.009] but not stroke [23 (0.6 ) vs 32 (0.8 ); OR, 0.76; 95 CI, 0.44-1.33; P=0.34], death [96 (2.5 ) vs 111 (2.8 ); OR, 0.87; 95 CI, 0.65-1.17; P=0.37] or clinically significant hypotension [522 (13.4 ) vs 484 (12.1 ); OR, 1.13; 95 CI, 0.99-1.30; P=0.08]. Thoracic epidural with general anaesthesia was associated with a worse primary outcome than general anaesthesia alone [86 (12.1 ) vs 119 (5.4 ); OR, 2.95; 95 CI, 2.00-4.35; P
Original languageEnglish
Pages (from-to)382 - 390
Number of pages9
JournalBritish Journal of Anaesthesia
Volume111
Issue number3
DOIs
Publication statusPublished - 2013

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