Neural regulation of pancreatic cancer: a novel target for intervention

Aeson Chang, Corina Kim-Fuchs, Caroline P Le, Frederic Hollande, Erica K Sloan

Research output: Contribution to journalArticleResearchpeer-review

11 Citations (Scopus)

Abstract

The tumor microenvironment is known to play a pivotal role in driving cancer progression and governing response to therapy. This is of significance in pancreatic cancer where the unique pancreatic tumor microenvironment, characterized by its pronounced desmoplasia and fibrosis, drives early stages of tumor progression and dissemination, and contributes to its associated low survival rates. Several molecular factors that regulate interactions between pancreatic tumors and their surrounding stroma are beginning to be identified. Yet broader physiological factors that influence these interactions remain unclear. Here, we discuss a series of preclinical and mechanistic studies that highlight the important role chronic stress plays as a physiological regulator of neural-tumor interactions in driving the progression of pancreatic cancer. These studies propose several approaches to target stress signaling via the β-adrenergic signaling pathway in order to slow pancreatic tumor growth and metastasis. They also provide evidence to support the use of β-blockers as a novel therapeutic intervention to complement current clinical strategies to improve cancer outcome in patients with pancreatic cancer.
Original languageEnglish
Pages (from-to)1292-1312
Number of pages21
JournalCancers
Volume7
Issue number3
DOIs
Publication statusPublished - 2015

Keywords

  • Beta-adrenergic
  • Beta-blockers
  • Metastasis
  • Neural
  • Pancreatic cancer
  • Stress

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