Projects per year
Abstract
The tumor microenvironment is known to play a pivotal role in driving cancer progression and governing response to therapy. This is of significance in pancreatic cancer where the unique pancreatic tumor microenvironment, characterized by its pronounced desmoplasia and fibrosis, drives early stages of tumor progression and dissemination, and contributes to its associated low survival rates. Several molecular factors that regulate interactions between pancreatic tumors and their surrounding stroma are beginning to be identified. Yet broader physiological factors that influence these interactions remain unclear. Here, we discuss a series of preclinical and mechanistic studies that highlight the important role chronic stress plays as a physiological regulator of neural-tumor interactions in driving the progression of pancreatic cancer. These studies propose several approaches to target stress signaling via the β-adrenergic signaling pathway in order to slow pancreatic tumor growth and metastasis. They also provide evidence to support the use of β-blockers as a novel therapeutic intervention to complement current clinical strategies to improve cancer outcome in patients with pancreatic cancer.
Original language | English |
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Pages (from-to) | 1292-1312 |
Number of pages | 21 |
Journal | Cancers |
Volume | 7 |
Issue number | 3 |
DOIs | |
Publication status | Published - 2015 |
Keywords
- Beta-adrenergic
- Beta-blockers
- Metastasis
- Neural
- Pancreatic cancer
- Stress
Projects
- 3 Finished
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Adrenergic regulation of tumor inflammation and metastatic dissemination
Sloan, E. & Lane, R.
NIH - National Institutes of Health (United States of America)
1/04/13 → 31/03/17
Project: Research
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Role of claudin-2 on the development of Colorectal cancer metastases and their resistance to treatment
Sloan, E. & Hollande, F.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/13 → 31/12/15
Project: Research
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Sympathetic nervous system regulation of the tumour microenvironment
Sloan, E., Pouton, C., Mileshkin, L. & Moeller, A.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/11 → 31/12/13
Project: Research