Neural evidence that conscious awareness of errors is reduced in depression following a traumatic brain injury

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Abstract

Impaired error awareness is related to poorer outcome following traumatic brain injury (TBI). Error awareness deficits are also found in major depressive disorder (MDD), but have not been examined in the MDD that follows a TBI (TBI-MDD). This study assessed neural activity related to error awareness in TBI-MDD. Four groups completed a response inhibition task while EEG was recorded- healthy controls (. N=. 15), MDD-only (. N=. 15), TBI-only (. N=. 16), and TBI-MDD (. N=. 12). Error related EEG activity was compared using powerful randomisation statistics that included all electrodes and time points. Participants with TBI-MDD displayed less frontally distributed neural activity, suggesting reduced contribution from frontal generating sources. Neural activity during this time window is thought to reflect conscious awareness of errors. The TBI-only and MDD-only groups did not differ from controls, and early error processing was unaffected, suggesting early error detection is intact
Original languageEnglish
Pages (from-to)1 - 10
Number of pages10
JournalBiological Psychology
Volume106
DOIs
Publication statusPublished - 2015

Cite this

@article{dd8e106ddd014d318b8c2026c9f239a8,
title = "Neural evidence that conscious awareness of errors is reduced in depression following a traumatic brain injury",
abstract = "Impaired error awareness is related to poorer outcome following traumatic brain injury (TBI). Error awareness deficits are also found in major depressive disorder (MDD), but have not been examined in the MDD that follows a TBI (TBI-MDD). This study assessed neural activity related to error awareness in TBI-MDD. Four groups completed a response inhibition task while EEG was recorded- healthy controls (. N=. 15), MDD-only (. N=. 15), TBI-only (. N=. 16), and TBI-MDD (. N=. 12). Error related EEG activity was compared using powerful randomisation statistics that included all electrodes and time points. Participants with TBI-MDD displayed less frontally distributed neural activity, suggesting reduced contribution from frontal generating sources. Neural activity during this time window is thought to reflect conscious awareness of errors. The TBI-only and MDD-only groups did not differ from controls, and early error processing was unaffected, suggesting early error detection is intact",
author = "Neil Bailey and Hoy, {Kate Elizabeth} and Maller, {Jerome Joseph} and Upton, {Daniel John} and Segrave, {Rebecca Anne} and Bernadette Fitzgibbon and Fitzgerald, {Paul Bernard}",
year = "2015",
doi = "10.1016/j.biopsycho.2015.01.011",
language = "English",
volume = "106",
pages = "1 -- 10",
journal = "Biological Psychology",
issn = "0301-0511",
publisher = "Elsevier",

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TY - JOUR

T1 - Neural evidence that conscious awareness of errors is reduced in depression following a traumatic brain injury

AU - Bailey, Neil

AU - Hoy, Kate Elizabeth

AU - Maller, Jerome Joseph

AU - Upton, Daniel John

AU - Segrave, Rebecca Anne

AU - Fitzgibbon, Bernadette

AU - Fitzgerald, Paul Bernard

PY - 2015

Y1 - 2015

N2 - Impaired error awareness is related to poorer outcome following traumatic brain injury (TBI). Error awareness deficits are also found in major depressive disorder (MDD), but have not been examined in the MDD that follows a TBI (TBI-MDD). This study assessed neural activity related to error awareness in TBI-MDD. Four groups completed a response inhibition task while EEG was recorded- healthy controls (. N=. 15), MDD-only (. N=. 15), TBI-only (. N=. 16), and TBI-MDD (. N=. 12). Error related EEG activity was compared using powerful randomisation statistics that included all electrodes and time points. Participants with TBI-MDD displayed less frontally distributed neural activity, suggesting reduced contribution from frontal generating sources. Neural activity during this time window is thought to reflect conscious awareness of errors. The TBI-only and MDD-only groups did not differ from controls, and early error processing was unaffected, suggesting early error detection is intact

AB - Impaired error awareness is related to poorer outcome following traumatic brain injury (TBI). Error awareness deficits are also found in major depressive disorder (MDD), but have not been examined in the MDD that follows a TBI (TBI-MDD). This study assessed neural activity related to error awareness in TBI-MDD. Four groups completed a response inhibition task while EEG was recorded- healthy controls (. N=. 15), MDD-only (. N=. 15), TBI-only (. N=. 16), and TBI-MDD (. N=. 12). Error related EEG activity was compared using powerful randomisation statistics that included all electrodes and time points. Participants with TBI-MDD displayed less frontally distributed neural activity, suggesting reduced contribution from frontal generating sources. Neural activity during this time window is thought to reflect conscious awareness of errors. The TBI-only and MDD-only groups did not differ from controls, and early error processing was unaffected, suggesting early error detection is intact

UR - http://www.sciencedirect.com/science/article/pii/S0301051115000216

U2 - 10.1016/j.biopsycho.2015.01.011

DO - 10.1016/j.biopsycho.2015.01.011

M3 - Article

VL - 106

SP - 1

EP - 10

JO - Biological Psychology

JF - Biological Psychology

SN - 0301-0511

ER -